IJERPH, Vol. 15, Pages 1048: Reconciling the Entomological Hazard and Disease Risk in the Lyme Disease System

IJERPH, Vol. 15, Pages 1048: Reconciling the Entomological Hazard and Disease Risk in the Lyme Disease System International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15051048 Authors: Max McClure Maria Diuk-Wasser Lyme disease (LD) is a commonly cited model for the link between habitat loss and/or fragmentation and disease emergence, based in part on studies showing that forest patch size is negatively related to LD entomological risk. An equivalent relationship has not, however, been shown between patch size and LD incidence (LDI). Because entomological risk is measured at the patch scale, while LDI is generally assessed in relation to aggregate landscape statistics such as forest cover, we posit that the contribution of individual patches to human LD risk has not yet been directly evaluated. We design a model that directly links theoretical entomological risk at the patch scale to larger-scale epidemiological data. We evaluate its predictions for relative LD risk in artificial landscapes with varying composition and configuration, and test its ability to predict countywide LDI in a 12-county region of New York. On simulated landscapes, we find that the model predicts a unimodal relationship between LD incidence and forest cover, mean patch size, and mean minimum distance (a measure of isolation), and a protective effect for percolation probability (a measure of connectivity). In New York, risk indices generated by this model are signif...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research

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Harms and colleagues advised a single dose of doxycycline to prevent Lyme disease from a Ixodes ricinus tick bite.1 Using a modified-intention-to-treat analysis, the authors that reported a single 200 mg dose of doxycycline resulted in a 67% relative risk reduction for the subjects in the treatment arm.
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