IP229. Fatty Acid Synthase Expression in Peripheral Arterial
Diabetic patients exhibit distinct patterns of diffuse and recalcitrant peripheral artery disease, which subsequently predisposes them to poor wound healing, infection, and critical limb ischemia. Fatty acid synthase (FAS), an enzyme responsible for de novo fatty acid synthesis, exhibits elevated content in the liver tissue in diabetic mouse models and elevated serum levels in diabetic patients with carotid artery stenosis. It is currently unknown whether tissue FAS and serum circulating FAS (cFAS) correlate with diabetic status in patients with femoral arterial occlusive disease.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Kshitij A. Desai, Gayan DeSilva, Chao Yang, Luis A. Sanchez, Clay F. Semenkovich, Mohamed Zayed Source Type: research
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