PC238. The Effect of Ischemia on Adipose-Derived Mesenchymal Stem Cells Expression In Vivo

Several animal models have demonstrated improvement in mesenchymal stem cells (MSCs) count and paracrine secretions under hypoxic conditions. We have demonstrated an increase in adipose derived mesenchymal stem cells (ADMSCs) count in ischemic compared with nonischemic tissues in a previous in vivo study. This follow-up study was performed to investigate the effect of critical limb ischemia, in a human model, on in-situ ADMSCs paracrine effects.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research