Nipah virus outbreak 'claims ten lives' in India

Medical camps have been set up in the Kerala region of India as dozens of people are thought to be infected with the deadly Nipah virus, and five people are confirmed to have died of it already.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Conclusion: The rapid spread of infection uncovered the miserable state of health care system in implementing infection control measures. The case fatality and the socio-economic burden warrant developing appropriate treatments, vaccines and diagnostics.
Source: Journal of Global Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
[IPS] Colombo, Sri Lanka -In the wake of the latest coronavirus outbreak, movie buffs are drawing an eerie parallel with the film Contagion, a 2011 thriller based on a lethal airborne virus called Nipah and how the world's medical community battled to find a cure for the pandemic.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
They are considered the probable source of the coronavirus outbreak spreading from China. It turns out that they may have an immune system that lets them coexist with many disease-causing viruses.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Bats Viruses Epidemics Coronavirus (2019-nCoV) Marburg Virus Nipah Virus Hendra Virus SARS (Severe Acute Respiratory Syndrome) MERS (Middle East Respiratory Syndrome) Immune System Cell Host and Microbe (Journal) EcoHealth Alliance Source Type: news
Publication date: Available online 12 January 2020Source: Microbial PathogenesisAuthor(s): Gerard Kian-Meng Goh, A. Keith Dunker, James A. Foster, Vladimir N. UverskyAbstractThe Nipah Virus (NiV) was first isolated during a 1998–9 outbreak in Malaysia. The outbreak initially infected farm pigs and then moved to humans from pigs with a case-fatality rate (CFR) of about 40%. After 2001, regular outbreaks occurred with higher CFRs (∼71%, 2001–5, ∼93%, 2008–12). The spread arose from drinking virus-laden palm date sap and human-to-human transmission. Intrinsic disorder analysis revealed strong correla...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
In this study, we tested ALS-8112 against NiV and other major human respiratory pneumo- and paramyxoviruses in 2 human lung epithelial cell lines, and demonstrated the ability of ALS-8112 to reduce infectious wild-type NiV yield by over 6 orders of magnitude with no apparent cytotoxicity. However, further cytotoxicity testing in primary cells and bone marrow progenitor cells indicated cytotoxicity at higher concentrations of ALS-8112. Our results warrant the evaluation of lumicitabine against NiV infection in relevant animal models.
Source: Antiviral Therapy - Category: Virology Source Type: research
In this study, we tested ALS-8112 against NiV and other major human respiratory pneumo- and paramyxoviruses in 2 human lung epithelial cell lines, and demonstrated the ability of ALS-8112 to reduce infectious wild-type NiV yield by over 6 orders of magnitude with no apparent cytotoxicity. However, further cytotoxicity testing in primary cells and bone marrow progenitor cells indicated cytotoxicity at higher concentrations of ALS-8112. Our results warrant the evaluation of lumicitabine against NiV infection in relevant animal models. PMID: 31935422 [PubMed - as supplied by publisher]
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
This week I attended the Nipah Virus International Conference in Singapore, marking the discovery of the virus 20 years ago. It’s an opportune time to recall the events around the emergence of this deadly pathogen. An outbreak of respiratory disease and encephalitis in pigs during 1998 took place in Ipoh City of Perak state in […]
Source: virology blog - Category: Virology Authors: Tags: Basic virology Information encephalitis fruit bat Hendra virus henipavirus Nipah virus pandemic Pteropus respiratory disease spillover viral viruses Source Type: blogs
In this study, we have considered all 9 Nipah proteins as potential therapeutic targets and computationally identified 4 putative peptide inhibitors (against G, F and M proteins) and 146 small molecule inhibitors (against F, G, M, N, and P proteins). The computations include extensive homology/ab initio modeling, peptide design and small molecule docking. An important contribution of this study is the increased structural characterization of Nipah proteins by approximately 90% of what is deposited in the PDB. In addition, we have carried out molecular dynamics simulations on all the designed protein-peptide complexes and o...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes frequent outbreaks of severe neurologic and respiratory disease in humans with high case fatality rates. The 2 glycoproteins displayed on the surface of the virus, NiV-G and NiV-F, mediate host-cell attachment and membrane fusion, respectively, and are targets of the...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
A deadly virus called Nipah carried by bats has already caused human outbreaks across South and South East Asia and has "serious epidemic potential", global health and infectious disease specialists said on Monday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
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