Trpc6 inactivation confers protection in a model of severe nephrosis in rats

We examined aminonucleoside nephrosis in rats with wild type and inactivated TRPC6.TRPC6 channels were inactivated by CRISPR/Cas9 editing of theTrpc6 gene.TRPC6 inactivation reduced albuminuria in the chronic but not the acute phase.TRPC6 inactivation reduced glomerulosclerosis and ultrastructural changes.TRPC6 inactivation also reduced interstitial changes and renal fibrosis.
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research