Women with pregnancy-related diabetes may be at risk for chronic kidney disease

(NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development) Gestational diabetes may predispose women to early-stage kidney damage, a precursor to chronic kidney disease, according to a study by researchers at the National Institutes of Health and other institutions. The study appears in Diabetes Care.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Authors: Hepp Z, Lage MJ, Espaillat R, Gossain VV Abstract OBJECTIVE: To evaluate outcomes associated with adherence to levothyroxine (LT4) in the US adult hypothyroidism population. METHODS: We used data from Truven's MarketScan databases from July 1, 2011 through December 31, 2015. Patients aged 18 or older were diagnosed with hypothyroidism (confirmed at least twice) and prescribed LT4. Patients were excluded if they did not have continuous insurance coverage or if they received a diagnosis of thyroid cancer or pregnancy during the study period. Multivariable analyses on a matched cohort of adherent and non-...
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
Gestational diabetes occurs only in pregnancy and results when the level of blood sugar is too high.
Source: National Institutes of Health (NIH) News Releases - Category: American Health Source Type: news
Publication date: Available online 11 April 2018 Source:Pregnancy Hypertension Author(s): Kirsty G. Pringle, Celine Corbisier de Meaultsart, Shane D. Sykes, Loretta J. Weatherall, Lyniece Keogh, Don C. Clausen, Gus A. Dekker, Roger Smith, Claire T. Roberts, Kym M. Rae, Eugenie R. Lumbers The intrarenal renin-angiotensin system (iRAS) is implicated in the pathogenesis of hypertension, chronic kidney disease and diabetic nephropathy. Urinary angiotensinogen (uAGT) levels reflect the activity of the iRAS and are altered in women with preeclampsia. Since Indigenous Australians suffer high rates and early onset of renal diseas...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
This study aimed to describe the prevalence of ARC in critically ill Indigenous Australian patients and explore the accuracy of commonly employed mathematical estimates of glomerular filtration. We completed a single-centre, prospective, observational study in the intensive care unit (ICU), Alice Springs Hospital, Central Australia. Participants were critically ill adult Indigenous and non-Indigenous Australian patients with a urinary catheter in situ. Exclusion criteria were anuria, pregnancy or the requirement for renal replacement therapy. Daily eight-hour measured creatinine clearances (CrCLm) were collected throughout...
Source: Anaesthesia and Intensive Care - Category: Anesthesiology Source Type: research
Conclusions GDM is associated with the subsequent development of albuminuria among black women in CARDIA.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
AbstractPurpose of ReviewWe reviewed the strategies associated with hypoglycemia risk reduction among critically ill non-pregnant adult patients.Recent FindingsHypoglycemia in the ICU has been associated with increased mortality in a number of studies. Insulin dosing and glucose monitoring rules, response to impending hypoglycemia, use of computerization, and attention to modifiable factors extrinsic to insulin algorithms may affect the risk for hypoglycemia. Recurring use of intravenous (IV) bolus doses of insulin in insulin-resistant cases may reduce reliance upon higher IV infusion rates.SummaryIn order to reduce the ri...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
Abstract The rate of pregnancy-associated acute kidney injury (P-AKI) has dwindled in high income countries mainly following the legalization of abortion in the seventies and early eighties and the general improvement in obstetrical care. P-AKI has not however disappeared from high income countries and several reports indicate that its frequency has even increased during the last decade. The reasons for such evolution are probably an improved surveillance and reporting of P-AKI and a more aggressive approach to the treatment of pregnancy complications, with unintended renal side effects. The characteristics of pre...
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
Conclusions: Our findings suggest that arsenic exposure is not associated with obesity, and that urinary creatinine and osmolality may be colliders on the causal pathway from arsenic exposure to obesity, as common descendants of hydration and body composition. In studies of urinary biomarkers and obesity or obesity-related outcomes, alternative metrics such as urinary flow rate or analytic strategies such as covariate-adjusted standardization should be considered. https://doi.org/10.1289/EHP1202 Received: 07 October 2016 Revised: 21 March 2017 Accepted: 30 March 2017 Published: 28 August 2017 Address correspondence t...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusion The present findings suggest that women with pre-eclampsia are at 2 to 3-fold increased risk of ESRD and 40% increased risk of CKD compared to parous women with no pre-eclampsia. The association was significant across a range of subgroup analyses.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Publication date: Available online 25 July 2017 Source:Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health Author(s): Effie Viguiliouk, Alison L. Park, Howard Berger, Michael P. Geary, Joel G. Ray An outstanding issue is how to efficiently identify women at high risk of preeclampsia. This retrospective cohort study included 8672 pregnancies at a single centre in Toronto. We tested our simple method – presence vs. absence of≥1 major (pre-pregnancy BMI>30kg/m2, chronic hypertension, pre-pregnancy diabetes mellitus and assisted reproductive therapy) or≥2 minor (prior stillbirth, a...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
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