TOX expression decreases with progression of colorectal cancers and is associated with CD4 T-cell density and Fusobacterium nucleatum infection

Fusobacterium nucleatum (F. nucleatum) in the tumor microenvironment plays an important role in the development of colorectal cancer (CRC). The underlying mechanism of action, however, remains to be elucidated. We evaluated the relation of F. nucleatum amount to thymocyte selection-associated high-mobility group box (TOX) protein expression and CD4+ T cell density in 138 human colorectal tissues. TOX expression and CD4+ T cell density in F. nucleatum negative tissues were significantly higher compared to those in F.

Source: Human Pathology - May 21, 2018 Category: Pathology Authors: Ting Chen, Qing Li, Xiaoyan Zhang, Ran Long, Yaxin Wu, Jiao Wu, Xiangsheng Fu Tags: Original Contributions Source Type: research