Sub-chronic celecoxib prevents soluble beta amyloid-induced depressive-like behavior in rats

Depressive states have been linked to the development of neurodegenerative disorders such as Alzheimer's disease (AD). Indeed, depression is a common feature in early AD representing a clinical manifestation of this disease before cognitive decline (Visser  et al., 2000). Depression has been indicated as a risk factor for AD and depressed subjects, mild cognitive impaired, show more than twice the risk of developing AD-type dementia than non-depressed (Modrego and Ferrandez, 2004). In this regard, neuropsychiatric symptoms have been reported as pr odromal symptoms of dementia deriving from neurobiological changes in specific cerebral regions (Andersen et al., 2005).
Source: Journal of Affective Disorders - Category: Neurology Authors: Source Type: research