Exploring new treatment paradigms for alcoholic hepatitis by extrapolating from NASH and cholestasis

Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease with 30-day mortality rate of up to 30%.[1] Corticosteroids are currently the only effective therapy but provide at best only short-term survival benefit.[2] Therefore, there is an urgent need to identify novel therapeutic targets for this lethal condition. Important pathways that have been the focus of treatment investigations include (1) bacterial and endotoxin translocation through disrupted gut barrier function (e.g.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research