Major bleeding with old and novel oral anticoagulants: How to manage it: Focus on reversal agents

Even though vitamin K antagonists (VKAs) have been employed for>50  years, there is still some uncertainty about the best strategy to reverse anticoagulation due to VKAs in cases of major bleeding. Furthermore, there is also scarce evidence about the most appropriate way to treat serious bleeding associated with non-vitamin K antagonist oral anticoagulants. This review analyses the main advantages and disadvantages of the various forthcoming therapeutic options to restore a normal coagulation status in anticoagulated patients with ongoing serious bleeding.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research