Glutathione system in animal model of solid tumors: From regulation to therapeutic target

Glutathione (GSH) is involved in scavenging reactive oxygen species (ROS) to maintain antioxidant defenses and regulate redox-dependent cell signaling (Masella et al., 2005). GSH is also involved in several metabolic processes, including the synthesis of proteins and DNA, enzyme activity, metabolism, gene expression, signal transduction, and the intensification of cytoplasmic and transmembrane transport (Meister and Anderson, 1983; Zmorzy ński et al., 2015). The detoxification of xenobiotics and endogenous compounds is another relevant function of GSH (Ballatori et al., 2009).
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research