NIH-funded researchers identify target for chikungunya treatment

(NIH/National Institute of Allergy and Infectious Diseases) Scientists have identified a molecule found on human cells and some animal cells that could be a target for drugs against chikungunya virus infection and related diseases, according to new research published in the journal Nature. A team led by scientists at Washington University School of Medicine in St. Louis conducted the research, which was funded in part by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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We describe the unexpected binding of S-layer to cells devoid of DC-SIGN but also confirm that the presence of DC-SIGN was essential for S-layer’s antiviral activity. S-layer protein exerted its antiviral effect with different kinetics than mannan, a known viral inhibitor that also acts on DC-SIGN (Yu et al., 2017). Together our results suggest that inhibition of viral entry by S-layer occurs via a novel S-layer/DC-SIGN interaction. Materials and Methods Isolation of S-Layer Proteins S-layer proteins were extracted from overnight cultures of L. acidophilus ATCC 4356 cells grown in MRS medium at 37°C by using 6...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Tapas Kumar Nayak1†, Prabhudutta Mamidi2, Subhransu Sekhar Sahoo1, P. Sanjai Kumar1, Chandan Mahish1, Sanchari Chatterjee2, Bharat Bhusan Subudhi3, Soma Chattopadhyay2 and Subhasis Chattopadhyay1* 1School of Biological Sciences, National Institute of Science Education and Research, HBNI, Bhubaneswar, India2Infectious Disease Biology, Institute of Life Sciences, Bhubaneswar, India3School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar, India Chikungunya virus (CHIKV), a mosquito-borne Alphavirus, is endemic in different parts of the globe. The host macrophages are identified as the maj...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Confirmed cases of chikungunya virus in travelers returning from Thailand's tourist areas mean that visitors to the country are at increased risk, and the virus may spread to other nations, researchers warn.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
Conclusion The results obtained from this research shows, in general, the fragility in the social and political infrastructure necessary to improve the living conditions of populations, particularly those that depend on family agriculture in drought prone areas. The conditions of social, economic and environmental vulnerabilities presented in the region can be amplified by the drought process, and can aggravate the impacts resulting drought events, thus disadvantaging the population of this region, as shown in the Fig. 1. The general perception of the interviewees of the health sector shows an agreement with what is found...
Source: PLOS Currents Disasters - Category: International Medicine & Public Health Authors: Source Type: research
This study accessed the patients information on demographic characteristics, physical signs and symptoms. Study population This is a cross-sectional and observational study carried out in Brazil during DENV and ZIKV epidemic occurred in 2016. Patients were assisted at the Healthy Unit UPA Coronel Antonino in Campo Grande, MS, Brazil from February to March of 2016. During the study 134 suspected arboviral infection cases were included and submitted to investigation. Patients presenting fever, rash during acute phase of infection (up to the 7th day after disease onset) followed by at least two of the following signals a...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
Zika virus (ZIKV) is a flavivirus that is primarily transmitted by Aedes aegypti, the mosquito vector also important in the transmission of the flaviviruses responsible for dengue fever, yellow fever and chikungunya. Due to occurrence in the same geographic regions, serological cross-reactivity, and similar, albeit often less severe clinical manifestations as dengue and chikungunya infections, ZIKV infection likely went undetected and/or misdiagnosed for many years. ZIKV is somewhat unique among flaviviruses in its ability to also be transmitted via sexual contact, non-sexual body fluids and perinatally.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Conclusions Epitopes reported in this study showed promiscuity, antigenicity as well as good binding affinity for the HLA classes. These epitopes will provide the baseline for development of efficacious vaccine for CHIKV.
Source: Asian Pacific Journal of Tropical Medicine - Category: Tropical Medicine Source Type: research
A phase 1 and 2 clinical trial of anexperimental vaccineagainst the viral disease chikungunya has begun enrolling a planned 180 healthy adult volunteers aged 18 to 45 years with funding by the National Institute of Allergy and Infectious Diseases (NIAID). The vaccine, known as MV-CHIKV, is a recombinant live-attenuated measles vaccine virus expressing chikungunya proteins that induce antibody production.
Source: JAMA - Category: General Medicine Source Type: research
A new Phase I/II clinical trial of MV-CHIKV sponsored by the National Institutes of Health ’s (NIH) National Institute of Allergy and Infectious Diseases (NIAID) for the prevention of the chikungunya virus has begun enrolling healthy adult subjects at…
Source: Drug Development Technology - Category: Pharmaceuticals Source Type: news
(NIH/National Institute of Allergy and Infectious Diseases) A clinical trial of an experimental vaccine to prevent infection with chikungunya virus is now enrolling healthy adult volunteers at sites in the United States.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
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