Epigenetic regulation in diabetes-associated oxidative stress and myocardial dysfunction

Diabetes is an important risk factor for ischemic heart disease and is associated with worse outcomes compared to non-diabetic patients following acute myocardial infarction (AMI). Specifically, the mortality following AMI was several times higher in diabetic patients compared to nondiabetics [1]. Emerging evidence indicates that hyperglycemia exerts long-lasting unfavorable effects on the cardiovascular system even after blood glucose normalization [2]. Short-term exposure to hyperglycemia may induce “Hyperglycemic memory” and cause long-lasting effects on myocardium [3].
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research