Influence of diet on axonal damage in the EAE mouse model of multiple sclerosis

Numerous studies have shown that diet influences the development of autoimmune diseases. However, the influence of diet on axonal damage occurring in EAE (experimental autoimmune encephalomyelitis) has not been examined. In the current study we compared changes in axonal damage and myelin thickness in spinal cords of sham- and MOG (myelin oligodendrocyte glycoprotein) peptide-immunized mice kept on a standard mouse chow (Teklad 7012) versus AIN-93  M chow which was developed for improved animal health.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research