Hypofractionated radiotherapy is superior to conventional fractionation in an orthotopic model of anaplastic thyroid cancer.

Hypofractionated radiotherapy is superior to conventional fractionation in an orthotopic model of anaplastic thyroid cancer. Thyroid. 2018 May 18;: Authors: Oweida AJ, Phan A, Vancourt B, Robin T, Hararah MK, Bhatia S, Milner D, Lennon S, Pike L, Raben D, Haugen BR, Pozdeyev N, Schweppe RE, Karam SD Abstract Anaplastic thyroid cancer is an aggressive and highly lethal disease with poor outcomes and resistance to therapy. Despite multimodality treatment including radiation therapy and chemotherapy, response rates remain below 15% with a median time to progression of less than 3 months. Recent advances in radiotherapy delivery and gene-expression profiling may help guide patient selection for personalized therapy. The purpose of this study was to characterize the response to radiation in a panel of ATC cell lines and to test alternative radiotherapy fractionation schedules for overcoming radioresistance. We characterized the cellular response to radiation based on clonogenic assays and correlated radioresistance with microarray gene-expression profiling. Radioresistant cell lines had higher levels of CXCR4 compared to radiosensitive cell lines. We further tested hypofractionated RT in an orthotopic ATC tumor model and assayed tumor growth locally and distantly with in vivo and ex vivo bioluminescence imaging. Compared to conventionally fractionated RT, hypofractionated RT resulted in significantly improved tumor growth delay, decreased...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research