Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion

Publication date: Available online 19 May 2018 Source:Stem Cell Research Author(s): Yuko Arioka, Itaru Kushima, Hisako Kubo, Daisuke Mori, Norio Ozaki Astrotactin-2, encoded by ASTN2, is implicated in neuronal migration. Although genetic studies of schizophrenia (SCZ) patients have suggested that exonic deletions of ASTN2 are associated with neurodevelopmental and psychiatric disorders, their biological significance remains unclear. Herein, we generated human induced pluripotent stem cells (iPSCs) from a SCZ patient with an exonic deletion of ASTN2. The generated iPSCs carried ASTN2 deletion and showed typical iPSC morphology, pluripotency marker expression, normal chromosomal aneuploidy, and the capacity to differentiate into three germ layers. This iPSC line may be suitable for evaluating Astrotactin-2 function relevant for SCZ onset in the human brain.
Source: Stem Cell Research - Category: Stem Cells Source Type: research