BODIPY-based Ir(III) rectangles containing bis-benzimidazole ligands with highly selective toxicity obtained through self-assembly

Publication date: 1 August 2018 Source:Journal of Organometallic Chemistry, Volume 868 Author(s): Gajendra Gupta, Abhishek Das, Seon Woong Lee, Ji Yeon Ryu, Junseong Lee, Narayana Nagesh, Nripendranath Mandal, Chang Yeon Lee Selectivity for cancerous cells over normal cells remains one of the most important issues in studies of the biological activities of metal-based drugs. Herein, we show that benzimidazole-based iridium BODIPY rectangles can be used to selectively kill cancer cells. New tetranuclear (2 + 2) metalla-rectangles 1 and 2 were synthesized through the self-assembly of benzimidazole and BODIPY ligands with dichloro (pentamethylcyclopentadienyl) iridium dimer. The new complexes were fully characterized using different analytical techniques and a single-crystal structure was obtained for rectangle 2. Cytotoxicity studies revealed that complex 1 is highly selective for cervical cancer cells (HeLa) and human glioblastoma (U87) cancer cells over non-malignant lung fibroblast cells (WI38). The selectivity of complex 1 is much superior than that of well-known drug cisplatin. The cellular uptake and intracellular localization of these complexes were examined through confocal microscopy studies, and complex 1 was found to localize primarily in the cytoplasmic region of cancer cells. Furthermore, the interactions of these complexes with biomolecules in solution were investigated through spectroscopic studies. Graphical abstract
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research

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The objective of this study is to assess information, motivation, and behavioral skills associated with willingness to receive an HPV test instead of a Pap test among women. The sample included U.S. 812 women, ages 30 to 65 years. Participants completed an online survey in 2018. The Information, Motivation, and Behavioral Skills (IMB) model was used to measure predictors of willingness for HPV testing. The outcome variables were willingness to receive the HPV test instead of the Pap test, with and without time interval details. Logistic regression modeling was used with SAS 9.4. Over half of the sample (55%) were willing...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
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Source: Journal of Cancer Policy - Category: Cancer & Oncology Source Type: research
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Source: International Journal of Surgical Oncology - Category: Surgery Tags: Int J Surg Oncol Source Type: research
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Source: Canadian Medical Association Journal - Category: General Medicine Tags: CMAJ Source Type: research
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Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Cell Death &Disease, Published online: 20 November 2019; doi:10.1038/s41419-019-2117-9Upregulation of IGF2R evades lysosomal dysfunction-induced apoptosis of cervical cancer cells via transport of cathepsins
Source: Cell death and disease - Category: Internal Medicine Authors: Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
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Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Family Medicine, Gynecology, Internal Medicine, Oncology, Pathology, Journal, Source Type: news
Authors: Feng Y, Liu H, Ding Y, Zhang Y, Liao C, Jin Y, Ai C Abstract PURPOSE: To prospectively investigate changes in quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and the apparent diffusion coefficient (ADC) of diffusion-weighted imaging (DWI) in patients with cervical cancer before and after neoadjuvant chemotherapy (NACT). METHODS: Thirty-eight patients with cervical cancer underwent DCE-MRI and DWI 1 week before and 4 weeks after NACT. The patients were classified into 2 groups: significant reaction (sCR) group and the non-sCR group. DCE-MRI parameters and ADC va...
Source: Tumori - Category: Cancer & Oncology Tags: Tumori Source Type: research
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Source: - Pharma News - Category: Pharmaceuticals Source Type: news
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