Intensity modulated radiotherapy and brachytherapy for a cervical cancer after renal transplantation.

Intensity modulated radiotherapy and brachytherapy for a cervical cancer after renal transplantation. Eur J Gynaecol Oncol. 2017;38(1):162-165 Authors: Yang L, Zhang X, Lv X, Yu H Abstract Radiotherapy and surgery are important radical treatment options for cervical cancer, but the presence of a pelvic kidney complicates the situation. Fine radiation technique can help avoiding side effects. Radiation to the modified pelvis using intensity modulated radiotherapy (IMRT) followed by brachytherapy, while avoiding the renal allograft is technically feasible which ensures adequate target volume and reduces side effects. Here, the authors report a 45-year-old patient with invasive cervical cancer with a pelvic kidney who was treated by pelvic IMRT in combination with high-dose rate brachytherapy. There was no evidence of disease and with normal kidney function currently at 12 months. PMID: 29767890 [PubMed - in process]
Source: European Journal of Gynaecological Oncology - Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Related Links:

Robert Chelsea turned down the first face he was offered. It was a fine face, one that could have taken him off the transplant waiting list after just a couple months. But Chelsea—severely disfigured after a catastrophic car accident five years earlier—was in no hurry. He’d gotten used to tilting his head back so food and water wouldn’t fall out of his nearly lipless mouth. He knew how to respond compassionately to children who stared in shock and fear. The face, offered in May 2018, had belonged to a man with skin that was much fairer than what remained of Chelsea’s—so light that Chelse...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Healthcare Source Type: news
Mauricio Campos-Mora1,2, Pamina Contreras-Kallens1, Felipe Gálvez-Jirón1, Masyelly Rojas1, Carolina Rojas3, Aarón Refisch1, Oscar Cerda2,4 and Karina Pino-Lagos1* 1Centro de Investigación Biomédica, Facultad de Medicina, Universidad de los Andes, Las Condes, Chile 2Programa de Biología Celular y Molecular, Facultad de Medicina, Instituto de Ciencias Biomédicas (ICBM), Universidad de Chile, Santiago, Chile 3Facultad de Odontología, Universidad de Chile, Santiago, Chile 4Millennium Nucleus of Ion Channel Associated Diseases (MiNICAD), Universidad de Chile, San...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: This case of thyroid bed PG supports the idea that PG reflects a cutaneous phenotype encompassed in the spectrum of systemic neutrophilic diseases. Endocrinologists should be aware that thyroid bed PG involvement is an albeit rare differential diagnosis to consider in patients who had undergone thyroid surgery, especially with a history of PG. Introduction Papillary thyroid carcinoma (PTC), the main variant of differentiated thyroid carcinoma (DTC), is the most common thyroid cancer, accounting for 70–80% of all thyroid carcinomas and occurring predominantly in women, generally with a good prognos...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
In this study, Lactobacillus plantarum (L. plantarum) KLDS1.0318 preserved in our laboratory was orally administered to CTX-treated mice to explore its potential effects to attenuate the toxic effects of CTX-induced by modulating intestinal immune response, promoting intestinal integrity and improving metabolic profile. BALB/c mice were randomly divided into six groups including normal control group (NC; non-CTX with sterile saline), model control group (MC; CTX-treated with sterile saline), CTX-treated with L. plantarum KLDS1.0318 (10 mL/kg) groups with three different doses (KLDS1.0318-L, 5 × 107 CFU/mL; KLDS1.0318...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Discussion Suppressor of cytokine signaling 1 is an essential molecule for maintaining immune homeostasis and subverting inflammation. Disorders arising from excess inflammation or SOCS1 deficiency can be potentially treated with SOCS1 mimetics (Ahmed et al., 2015). While SOCS1 has promising potential in many disorders, it should be noted that new targets and actions of SOCS1 are still being discovered and not all the effects of this protein are beneficial in autoimmune diseases and cancer. For instance, SOCS1 degrades IRS1 and IRS2, required for insulin signaling, via the SOCS Box domain, thus, limiting its potential in ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: Mesenchymal stem cell transplantation could be use as a potential treatment for PHLF. Introduction Partial hepatectomy is an important treatment for benign and malignant liver diseases. Although the liver can be completely regenerated after partial excision or injury, at least 1/3 of the liver should be retained in most of the patients, and 40–50% should be retained in patients with parenchymal liver disease (Adams et al., 2013; Cieslak et al., 2014). Postoperative complications, such as acute post-hepatectomy liver failure (PHLF) or small liver syndrome, may occur when the scope of excision is to...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Cervical cancer is the most common gynecological cancer worlwide. Squamous intraepithelial lesions (SIL) are known precursors for carcinoma of uterine c èrvix and associated to infection by human papillomavirus (HPV). Several studies have shown an increased risk of malignant anogenital lesions in recipients of kidney and liver transplants compared to the general population, but there is less information in heart transplanted recipient
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 987 Source Type: research
On an afternoon in November, a couple hosted a birthday party for their 1-year-old son. As family and friends gathered around the child to sing “Happy Birthday,” his parents addressed a milestone that reached well beyond the room. “It was emotional,” recalls the mother. “It took a lot more than a nine-month pregnancy to get him, and we wouldn’t be where we are without everyone’s support.” Many parents will tell you their child is miraculous. But the mere existence of this particular boy, who just a month earlier had taken his first steps, brings the miracle somehow closer to ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized fertility Research Source Type: news
Objectives The ideal frequency of cervical cancer screening in women with solid organ transplants (SOTs) remains to be determined. We aimed to assess the longitudinal rates of cytologic and histologic cervical abnormalities in women after SOT. Methods We retrospectively reviewed health records of women aged 18 to 60 years who received their first kidney, liver, pancreas, or combination transplant at Mayo Clinic (Rochester, Minnesota) from 1995 through 2011. Patient demographics, cervical cytology and histology, and high-risk human papillomavirus (hrHPV) testing data were abstracted. All women included in the study had...
Source: Journal of Lower Genital Tract Disease - Category: OBGYN Tags: Original Research Articles: Cervix and HPV Source Type: research
Chronic immunosuppression constitutes a risk factor of HPV-related cervical cancer development. Maintenance immunosuppression with mTOR inhibitors is associated with decreased incidence of de novo malignancies in kidney graft recipients. Recently published data suggest that mTOR inhibitors interfere with viral replication. The aim of the study was to assess if there is a difference in prevalence of HPV cervical infection in female on immunosuppressive regimens with or without mTOR inhibitors.
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Source Type: research
More News: Bone Graft | Brachytherapy | Cancer | Cancer & Oncology | Cervical Cancer | Intensity-Modulated Radiation Therapy | Kidney Transplant | Kidney Transplantation | OBGYN | Transplants | Urology & Nephrology