β-Hydroxybutyrate protects from alcohol-induced liver injury via a Hcar2-cAMP dependent pathway

Excess alcohol intake has many effects on the liver and can present with several clinical syndromes.1 One of the most serious is acute alcoholic hepatitis (AH), which occurs unexpectedly after decades of high levels of alcohol consumption, and is characterized by sterile liver inflammation, jaundice and can progress to a systemic inflammatory response.2 There is a mixed inflammatory infiltrate characterized by neutrophils, and upregulation of a variety of inflammatory cytokines including IL-1 β, TNF-α and IL-6.

Source: Journal of Hepatology - April 26, 2018 Category: Gastroenterology Authors: Yonglin Chen, Xinshou Ouyang, Rafaz Hoque, Irma Garcia-Martinez, Muhammad Nadeem Yousaf, Sarah Tonack, Stefan Offermanns, Laurent Dubuquoy, Alexandre Louvet, Philippe Mathurin, Veronica Massey, Bernd Schnabl, Ramon Alberola Bataller, Wajahat Zafar Mehal Tags: Research Article Source Type: research