Plasmapheresis in a Patient with Sarcoidosis Who Developed Multiple Myeloma and Massive Free Kappa Light Chains Nephropathy.

Plasmapheresis in a Patient with Sarcoidosis Who Developed Multiple Myeloma and Massive Free Kappa Light Chains Nephropathy. Isr Med Assoc J. 2018 May;5(20):324-326 Authors: Markel A, Habashe N, Aviv A, Monich O, Elmalah I, Marei N, Tovbin D PMID: 29761682 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research

Related Links:

CONCLUSION: Our results suggest that sarcoidosis is a new subset in the spectrum of paraneoplastic syndrome. We propose that lymphoproliferative disorders should be considered in patients with cutaneous sarcoidosis who have a poor response to conventional therapy or whose skin biopsy shows a significant number of mitoses. PMID: 29779211 [PubMed - as supplied by publisher]
Source: Clinical Lymphoma and Myeloma - Category: Cancer & Oncology Authors: Tags: Clin Exp Dermatol Source Type: research
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book's index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 1...
Source: Specified Life - Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
Authors: Kusaba K, Kojima K, Naito S, Taba M, Kai K, Ureshino H, Nishida Y, Kimura S Abstract Sarcoidosis predominantly affects the lungs, intrathoracic lymph nodes, and eyes; it less frequently affects the musculoskeletal system. We herein report a case of paraneoplastic sarcoidosis in a patient presenting with multiple myeloma. The patient developed ocular sarcoidosis and showed an increased (18)F-fluorodeoxyglucose uptake in the mediastinal lymph nodes and vertebral column. A lymph node specimen showed the histological features of sarcoidosis, while an examination of the vertebral tumor revealed myeloma. Althoug...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Abstract Thalidomide is a drug with interesting therapeutic properties but also with severe side effects, which require a careful and monitored use. Potential immunomodulatory, anti-inflammatory, anti-angiogenic and sedative properties make thalidomide a good candidate for the treatment of several diseases such as multiple myeloma. Through an increase in the degradation of TNFα-mRNA, thalidomide reduces the production of TNFα by monocytes and macrophages stimulated by lipopolysaccharide or by T lymphocytes induced by mitogenic stimuli. The decreased level of TNFα alters the mechanisms of intracel...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
Conclusions:Inflammatory neuropathies especially Lymphoma followed by Sjogrens syndrome was the most common diagnosis in patients with cranial neuropathy and peripheral nerve disorders. The peripheral nerve disorder localised to the root level in a majority of the patients in our cohort. This is likely secondary to blood–nerve barrier being most vulnerable at this level.Disclosure: Dr. Rodrigues has nothing to disclose. Dr. Dyck has nothing to disclose. Dr. Kao has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Neuromuscular and Clinial Neurophysiology (EMG): Peripheral Neuropathy II Source Type: research
We describe two cases of patients with sarcoidosis in whom pathologic bone marrow lesions were diagnosed on MRI scans. The magnetic resonance findings were non-specific and metastatic lesions or multiple myeloma were suspected. The case analysis serves to point to limitations of imaging studies in diagnosing bone sarcoidosis and underline the importance of cooperation between the radiologist and the clinician. The role of magnetic resonance imaging in the diagnostic algorithm for bone sarcoidosis should mostly focus on locating lesions, indicating biopsy sites and follow-up of abnormalities. PMID: 28508769 [PubMed - in process]
Source: Ortopedia, Traumatologia, Rehabilitacja - Category: Orthopaedics Authors: Tags: Ortop Traumatol Rehabil Source Type: research
Abstract OBJECTIVE: Presentation of the etiology, pathology, clinical course, radiology and differential diagnostics of skeletal sarcoidosis. PATHOANATOMICAL PRINCIPLES: Noncaseating epithelioid cell granulomas can trigger solitary, multiple or disseminated osteolysis, reactive osteosclerosis and/or granulomatous synovitis. INCIDENCE: The incidence of sarcoidosis is 10-12 per 100,000 inhabitants per year. Skeletal involvement is approximately 14 %. CLINICAL ASPECTS: Skeletal involvement occurs almost exclusively in the stage of lymph node and pulmonary manifestation. Most cases of skeletal in...
Source: Der Radiologe - Category: Radiology Authors: Tags: Radiologe Source Type: research
Conclusions Conclusions: Differentiation between lymphoma and some lymphadenopathy can be difficult on FDG PET/CT, especially with the tuberculous lymphadenitis. A tumor-specific tracer may be a better choice to solve the problem. Key words: FDG PET/CT; lymphoma; misdiagnosis; lymphadenopathy; tuberculous lymphadeniti s
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: MTA I: Leukemia/Lymphoma/Myeloma Posters Source Type: research
We report a 71-years old lady who presented to our hematology clinic with fever and easy fatiguability of 3 months duration and on investigations was found to have anemia and hypercalcemia. Direct Coomb’s test characterized the anemia as complement mediated (anti-C3d) hemolysis. Biochemical investigations revealed normal 25(OH) Vitamin D3 and suppressed Parathormone levels and a negative workup for plasma cell dyscrasias, sarcoidosis and autoimmune disorders. CT scan revealed a paravertebral mass with cervical, supraclavicular and abdominal lymphadenopathy along with splenomegaly and left pleural effusion. Biops...
Source: Indian Journal of Hematology and Blood Transfusion - Category: Hematology Source Type: research
Vidya Nair, Deepak Prajapat, Deepak TalwarLung India 2016 33(1):75-78Literature on concurrent association of sarcoidosis with lymphoproliferative malignancies other than lymphoma e.g. multiple myeloma is meager. The rarity of the situation prompted us to report this patient who was a 51-year-old woman with a 2-years history of breathlessness, cough with expectoration, chest pain and backache. Initial evaluation revealed mild anemia, increased alkaline phosphatase with chest skiagram showing both lower zone non homogenous opacities with calcified hilar lymph nodes. CECT chest showed mediastinal with bilateral hilar lymphade...
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
More News: General Medicine | Israel Health | Middle East Health | Myeloma | Sarcoidosis