Plasmapheresis in a Patient with Sarcoidosis Who Developed Multiple Myeloma and Massive Free Kappa Light Chains Nephropathy.

Plasmapheresis in a Patient with Sarcoidosis Who Developed Multiple Myeloma and Massive Free Kappa Light Chains Nephropathy. Isr Med Assoc J. 2018 May;5(20):324-326 Authors: Markel A, Habashe N, Aviv A, Monich O, Elmalah I, Marei N, Tovbin D PMID: 29761682 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research

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In conclusion, using newer sensitive imaging tool we detected 36 (9.2%) patients with serious pathologies before the first symptoms. Therefore we believe, that ¹F-FDG PET/CT imaging can be recommended to be done not only in all MGUS patients with suspected SMM or active MM, but also for early identification of other serious pathologies.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Tags: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Poster I Source Type: research
Conclusions: Elevated serum angiotensin converting enzyme (ACE) is a risk factor for recurrence in sarcoidosis patients, that may suggesting that patients with high granulomatous burden at the time of diagnose are more likely to relapse.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research
CONCLUSION: Our results suggest that sarcoidosis is a new subset in the spectrum of paraneoplastic syndrome. We propose that lymphoproliferative disorders should be considered in patients with cutaneous sarcoidosis who have a poor response to conventional therapy or whose skin biopsy shows a significant number of mitoses. PMID: 29779211 [PubMed - as supplied by publisher]
Source: Clinical Lymphoma and Myeloma - Category: Cancer & Oncology Authors: Tags: Clin Exp Dermatol Source Type: research
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book's index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 1...
Source: Specified Life - Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
Authors: Kusaba K, Kojima K, Naito S, Taba M, Kai K, Ureshino H, Nishida Y, Kimura S Abstract Sarcoidosis predominantly affects the lungs, intrathoracic lymph nodes, and eyes; it less frequently affects the musculoskeletal system. We herein report a case of paraneoplastic sarcoidosis in a patient presenting with multiple myeloma. The patient developed ocular sarcoidosis and showed an increased (18)F-fluorodeoxyglucose uptake in the mediastinal lymph nodes and vertebral column. A lymph node specimen showed the histological features of sarcoidosis, while an examination of the vertebral tumor revealed myeloma. Althoug...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Abstract Thalidomide is a drug with interesting therapeutic properties but also with severe side effects, which require a careful and monitored use. Potential immunomodulatory, anti-inflammatory, anti-angiogenic and sedative properties make thalidomide a good candidate for the treatment of several diseases such as multiple myeloma. Through an increase in the degradation of TNFα-mRNA, thalidomide reduces the production of TNFα by monocytes and macrophages stimulated by lipopolysaccharide or by T lymphocytes induced by mitogenic stimuli. The decreased level of TNFα alters the mechanisms of intracel...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
Conclusions:Inflammatory neuropathies especially Lymphoma followed by Sjogrens syndrome was the most common diagnosis in patients with cranial neuropathy and peripheral nerve disorders. The peripheral nerve disorder localised to the root level in a majority of the patients in our cohort. This is likely secondary to blood–nerve barrier being most vulnerable at this level.Disclosure: Dr. Rodrigues has nothing to disclose. Dr. Dyck has nothing to disclose. Dr. Kao has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Neuromuscular and Clinial Neurophysiology (EMG): Peripheral Neuropathy II Source Type: research
We describe two cases of patients with sarcoidosis in whom pathologic bone marrow lesions were diagnosed on MRI scans. The magnetic resonance findings were non-specific and metastatic lesions or multiple myeloma were suspected. The case analysis serves to point to limitations of imaging studies in diagnosing bone sarcoidosis and underline the importance of cooperation between the radiologist and the clinician. The role of magnetic resonance imaging in the diagnostic algorithm for bone sarcoidosis should mostly focus on locating lesions, indicating biopsy sites and follow-up of abnormalities. PMID: 28508769 [PubMed - in process]
Source: Ortopedia, Traumatologia, Rehabilitacja - Category: Orthopaedics Authors: Tags: Ortop Traumatol Rehabil Source Type: research
Abstract OBJECTIVE: Presentation of the etiology, pathology, clinical course, radiology and differential diagnostics of skeletal sarcoidosis. PATHOANATOMICAL PRINCIPLES: Noncaseating epithelioid cell granulomas can trigger solitary, multiple or disseminated osteolysis, reactive osteosclerosis and/or granulomatous synovitis. INCIDENCE: The incidence of sarcoidosis is 10-12 per 100,000 inhabitants per year. Skeletal involvement is approximately 14 %. CLINICAL ASPECTS: Skeletal involvement occurs almost exclusively in the stage of lymph node and pulmonary manifestation. Most cases of skeletal in...
Source: Der Radiologe - Category: Radiology Authors: Tags: Radiologe Source Type: research
Conclusions Conclusions: Differentiation between lymphoma and some lymphadenopathy can be difficult on FDG PET/CT, especially with the tuberculous lymphadenitis. A tumor-specific tracer may be a better choice to solve the problem. Key words: FDG PET/CT; lymphoma; misdiagnosis; lymphadenopathy; tuberculous lymphadeniti s
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: MTA I: Leukemia/Lymphoma/Myeloma Posters Source Type: research
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