Polycystin-1 dysfunction impairs electrolyte and water handling in a renal pre-cystic mouse model for adpkd.

In conclusion, our data indicate that PC1 is involved in renal Mg2+, Ca2+ and water handling, and its dysfunction resulting in a systemic electrolyte imbalance characterized by low serum electrolyte concentrations. PMID: 29767557 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29767557?dopt=Abstract

Source: Am J Physiol Renal P... - May 16, 2018 Category: Urology & Nephrology Authors: Verschuren EHJ, Mohammed SG, Leonhard WN, Overmars-Bos C, Veraar KAM, Hoenderop JGJ, Bindels RJM, Peters DJM, Arjona FJ Tags: Am J Physiol Renal Physiol Source Type: research