Antagonistic metabolites produced by the fungus Curvularia sp. BCC52426 against Aspergillus sp. BCC51998

Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Nantiya Bunbamrung, Chakapong Intaraudom, Aibrohim Dramae, Nattawut Boonyuen, Rungtiwa Chanthaket, Pranee Rachtawee, Pattama Pittayakhajonwut Four previously undescribed compounds, including (Z)-chloromonilinic acid B (1), (E)-chloromonilinic acid C (2), 4-chlorocurvularin (5), and 4-chlorocurvularinic acid (6), together with four known compounds, (E)-chloromonilinic acids A and B, pinselin, and anhydromevalonolactone, were isolated from the fungus Curvularia sp. BCC52426. The chemical structures were determined by comparing their NMR spectra to documented spectra of the related compounds and the isolated compounds were also appraised for antimicrobial activity and cytotoxicity. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

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Publication date: Available online 15 November 2019Source: Biotechnology ReportsAuthor(s): Pradeep Kumar, Balwant Singh, Vikram Thakur, Abhishek Thakur, Nandita Thakur, Deepak Pandey, Duni ChandAbstractTaxol® (generic name Paclitaxel) is a chemotherapeutic drug, effective against head, neck, breast, lung, bladder, ovary, and cervix cancers. Rising demands in chemotherapy and limited supply of natural taxol have ultimately increased the cost of the drug. Semi synthesis using taxol precursors is not able to meet the global supply and has intensified the need to find alternative ways of taxol production. In the present st...
Source: Biotechnology Reports - Category: Biotechnology Source Type: research
los G Abstract SUMMARYAspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological niche, the fungus has learned how to adapt and proliferate in hostile environments. This capacity has helped the fungus to resist and survive against human host defenses and, further, to be responsible for one of the most devastating lung infections in terms of morbidity and mortality. In this review, we will provide (i) a description of the biological cycle of A. fumigatus; (ii) a historical perspective of the spectrum of aspergillus disease and the current epidemiological status of these infec...
Source: Clinical Microbiology Reviews - Category: Microbiology Authors: Tags: Clin Microbiol Rev Source Type: research
Molecules, Vol. 24, Pages 4151: Synthesis and Antimicrobial Activity of Methoxy- Substituted γ-Oxa-ε-lactones Derived from Flavanones Molecules doi: 10.3390/molecules24224151 Authors: Witold Gładkowski Monika Siepka Tomasz Janeczko Edyta Kostrzewa-Susłow Jarosław Popłoński Marcelina Mazur Barbara Żarowska Wojciech Łaba Gabriela Maciejewska Czesław Wawrzeńczyk Six γ-oxa-ε-lactones, 4-phenyl-3,4-dihydro-2H-1,5-benzodioxepin-2-one (5a) and its five derivatives with methoxy groups in different positions of A and B rings (5b–f), were synthesized fr...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Authors: Petitdemange A, Martin A, Ruch Y, Chatron E, Karol A, Hansmann Y PMID: 31722863 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
This study reported a case of maxillary aspergillosis with a complete headache and eye pain after tooth extraction with a large abscess in the relative jaw. Tenderness in the right temporal, lower jaw numbness and right eye proptosis was found. Histopathological examination was the suggestion of maxillary sinusitis with a fungal ball of aspergillus. PMID: 31719967 [PubMed]
Source: Iranian Journal of Microbiology - Category: Microbiology Tags: Iran J Microbiol Source Type: research
In this study, ten essential oils (EOs), namely: thyme, clove, laveder, cumin, oregano, cinnamon, basil, rosemary, sage and lemongrass were tested against four strains of Aspergillus [Aspergillus flavus (SLO-B-201), Aspergillus parasiticus (SLO-B-219), Aspergillus ochraceus (SLO-B-245) and Aspergillus westerdijkiae (SLO-B-249)] isolated from bread samples. The Aspergillus strains were tested for potential production of mycotoxins by thin layer chromatography (TLC). The chemical composition of all tested EOs was identified by GC-MS and by gas chromatography with flame ionization detector (GC-FID). The antifungal activity, t...
Source: Food Control - Category: Food Science Source Type: research
nioł A series of 18 aminochalcone derivatives were obtained in yields of 21.5–88.6% by applying the classical Claisen-Schmidt reaction. Compounds 4–9, 14 and 16–18 with 4-ethyl, 4-carboxy-, 4-benzyloxy- and 4-benzyloxy-3-methoxy groups were novel, not previously described in the scientific literature. To determine the biological properties of the synthesized compounds, anticancer and antimicrobial activity assays were performed. Antiproliferative potential was evaluated on four different human colon cancer cell lines—HT-29, LS180, LoVo and LoVo/DX —using the SRB assay ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Aflatoxins pose significant food security and public health risks, decrease productivity and profitability of animal industries, and hamper trade. To minimize aflatoxin contamination in several crops, a biocontrol technology based on atoxigenic strains of Aspergillus flavus is commercially used in the United States and some African countries. Significant efforts are underway to popularize the use of biocontrol in Africa by various means including incentives. The purpose of this study was to develop quantitative pyrosequencing assays for rapid, simultaneous quantification of proportions of four A. flavus biocontrol genotype...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.9b00520
Source: Journal of Proteome Research - Category: Biochemistry Authors: Source Type: research
AbstractDiagnosis of onychomycosis requires microbiological studies, which are time-consuming. Dermoscopy is non invasive, easy and coastless method. To evaluate the diagnostic role of dermoscopy in onychomycosis and comparing its findings with microbiological results. Eighty patients with onychomycosis and 40 controls were studied for nail dermoscopic finding, and microbiological examinations in the form of microscopic examination by 20% KOH, Sabouraud dextrose agar (SDA), and HiCrome Candida Differential Agar. 72.5% of the patients were females. Most of the patient were presented with one finger (35%) and two fingers (35...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
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