Vitamin E Phosphate Coating Stimulates Bone Deposition in Implant-related Infections in a Rat Model.

CONCLUSIONS: These preliminary findings indicate that vitamin E phosphate implant coatings can exert a protective effect on bone deposition in a highly contaminated animal model of implant-related infection. CLINICAL RELEVANCE: The use of vitamin E coatings may open new perspectives for developing coatings that can limit septic loosening of infected implants with bacterial contamination. However, a deeper insight into the mechanism of action and the local release of vitamin E as a coating for orthopaedic implants is required to be used in clinics in the near future. Although this study cannot support the antimicrobial properties of vitamin E, promising results were obtained for bone-implant osseointegration. These preliminary results will require further in vivo investigations to optimize the host response in the presence of antibiotic prophylaxis. PMID: 29771856 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/29771856?dopt=Abstract

Source: Clinical Orthopaedics and Related Research - May 18, 2018 Category: Orthopaedics Authors: Lovati AB, Bottagisio M, Maraldi S, Violatto MB, Bortolin M, De Vecchi E, Bigini P, Drago L, Romanò CL Tags: Clin Orthop Relat Res Source Type: research