PavMed subsidiary Lucid Dx inks licensing deal with Case Western Univ.

Pavmed (NSDQ:PAVM) subsidiary Lucid Diagnostics said today it finalized a licensing agreement with Case Western Reserve University to commercialize its EsoCheck non-invasive cell sampling device and DNA biomarker test. The New York-based company said that the EsoCheck device has been shown to effectively and accurately detect Barrett’s Esophagus, which is a precursor to the most common and lethal forms of esophageal cancer caused by Gastroesophageal Reflux Disease. The EsoCheck test is composed of a pill-sized capsule with a small inflatable balloon attached to a thin catheter. The patient swallows the capsule, which swabs the target area for a sample of cells as it is withdrawn, the company said. Collected samples are then tested for biomarkers that have been shown to be accurate for detecting Barrett’s Esophagus. As part of the licensing agreement, PavMed’s Lucid Diagnostics will own the exclusive worldwide right to develop both the device and biomarker test and the associated intellectual property. “EsoCheck is a revolutionary technology that we believe will save many lives through the early detection of pre-cancerous conditions of the esophagus including Barrett’s Esophagus. We are proud to have been selected to be the exclusive commercial partner of Case Western Reserve University in this important endeavor. Based on the dramatic results of the recently published multicenter clinical study, we believe widespread EsoCheck screening has t...
Source: Mass Device - Category: Medical Devices Authors: Tags: Business/Financial News Diagnostics Otolaryngology Ear, Nose & Throat Pavmed Source Type: news

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Abstract Over twenty thousand persons rely on water from Atuwara River for drinking and other domestic purposes, hence the need to ascertain the human health risk inherent in such practice. Seventy-two water samples were collected from River Atuwara during the dry and wet seasons of 2018, and the concentration of heavy metals (Pb, As, Ni, Cr, Zn, Cu, and Cd) were measured using ICP-OES. A newly developed human health risk assessment method, HHRISK code was used to estimate the health risks associated with consumption of water from Atuwara River. Results obtained revealed that the concentration of heavy metals in t...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Abstract There is limited information about pesticide contamination in Iran's agricultural land, particularly in plains producing exportable fruits. The aim of this investigation was to evaluate the concentration of organochlorine pesticides (OCPs) including hexachlorocyclohexane (HCH), heptachlor, dichloro-diphenyl-trichloroethane (DDT), chlordane (CHL), and their isomers compounds in agricultural soils of southern Iran. A total of 28 topsoil samples were collected from agricultural lands of Dalaki and Shabankare areas, Bushehr, Iran. In Dalaki area, the mean value of ΣHCH (α, β, γ, δ...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Conclusion: ARL is a heterogeneous disease. Histologic subtype is a major determinant of the clinical outcome. ADL has significantly lower CD4 counts than those of NADL. There is an urgent and unmet need for uniform management guidelines for improving outcomes in this under-represented patient population. PMID: 31730692 [PubMed]
Source: Blood Research - Category: Hematology Tags: Blood Res Source Type: research
Authors: Fathi E, Sanaat Z, Farahzadi R Abstract Drug resistance in cancer, especially in leukemia, creates a dilemma in treatment planning. Consequently, studies related to the mechanisms underlying drug resistance, the molecular pathways involved in this phenomenon, and alternate therapies have attracted the attention of researchers. Among a variety of therapeutic modalities, mesenchymal stem cells (MSCs) are of special interest due to their potential clinical use. Therapies involving MSCs are showing increasing promise in cancer treatment and anticancer drug screening applications; however, results have been inc...
Source: Blood Research - Category: Hematology Tags: Blood Res Source Type: research
Conclusion: Our results suggest a greater role of nongenetic factors in PTP inhibitor development. PMID: 31730688 [PubMed]
Source: Blood Research - Category: Hematology Tags: Blood Res Source Type: research
CONCLUSIONS: neoadjuvant chemotherapy is a promising alternative in the locally advanced rectal cancer setting and further phase III clinical trials are clearly warranted. PMID: 31729235 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
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Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
Authors: Dib J Abstract I read with great interest the paper by Sousa M. Tumor seeding of the fistula tract should be suspected in patients with a previous history of esophageal or nasopharynx squamous cell carcinoma who have undergone a Percutaneous Endoscopic Gastrostomy (PEG) with a persistent gastrocutaneous fistula. Especially after the use of an OTSC. In fact, the "pull technique" for PEG tube placement should not be used in this context. PMID: 31729232 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
Herbs to increase breast milk supply and heal the spleen. Traditional remedies which promise to cure insomnia and acne. Secret cancer treatments that have been ignored or suppressed by Western medicine.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 26 September 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Kumar Padmapriya, Ritu BarthwalAbstractCoralyne is an important alkaloid due to its anti-cancer and other medicinal properties. It targets DNA in cells and acts as human topoisomerase-I poison, telomerase inhibitor and nucleic acid intercalator. It has high tendency to undergo self-association, which is a matter of concern for therapeutic applications. The understanding of its interaction with DNA requires precise knowledge of chemical shifts in Nuclear Magnetic Resonance (NMR) spectra besides self-association. The pres...
Source: Journal of Pharmaceutical Analysis - Category: Drugs & Pharmacology Source Type: research
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