Evaluation of malaria rapid diagnostic test (RDT) use by community health workers: a longitudinal study in western Kenya

Malaria rapid diagnostic tests (RDTs) are a simple, point-of-care technology that can improve the diagnosis and subsequent treatment of malaria. They are an increasingly common diagnostic tool, but concerns re...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research

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In this study we analyze the distribution of apicomplexans across a range of both host-associated and free-living environments. Using publicly available small subunit (SSU) rRNA gene databases, high-throughput environmental sequencing (HTES) surveys, and our own generated HTES data, we developed an apicomplexan reference database, which includes the largest apicomplexan SSU rRNA tree available to date and encompasses comprehensive sampling of this group and their closest relatives. This tree allowed us to identify and correct incongruences in the molecular identification of apicomplexan sequences. Analyzing the diversity a...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Date: Tuesday, 11 26, 2019; Speaker: Susan Pierce, Ph.D., Chief, Laboratory of Immunogenetics, NIAID; Building: 35; GF640
Source: NIH Calendar of Events - Category: American Health Source Type: events
Publication date: Available online 22 October 2019Source: Antiviral ResearchAuthor(s): Esther Oiknine-Djian, Shikma Bar-On, Ido Laskov, Daniel Lantsberg, Richard K. Haynes, Amos Panet, Dana G. WolfAbstractWe have recently shown that the artemisinin derivative artemisone, which was screened against malaria in human clinical studies, is a potent inhibitor of human cytomegalovirus (HCMV). Here we evaluated the antiviral effect of artemisone when employed in 2-drug combinations with approved and experimental anti-HCMV agents. Using the Chou-Talalay method, we found that in-vitro combination of artemisone with cidofovir, brinci...
Source: Antiviral Therapy - Category: Virology Source Type: research
[Global Fund] Lyon, France -At the opening of the Sixth Replenishment conference, the Global Fund announced a range of private sector partners that will spur innovation to accelerate the end to HIV, tuberculosis and malaria, the world's deadliest infectious diseases.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Climate change is making it harder to eradicate deadly epidemics, with rising temperatures helping mosquitoes spread malaria in higher places in Africa, the head of a global health fund said on Tuesday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
[Daily Trust] The Federal Government has pledged $12 million to the Global Fund to tackle HIV, tuberculosis and malaria.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
Human movement into insect vector and wildlife reservoir habitats determines zoonotic disease risks; however, few data are available to quantify the impact of land use on pathogen transmission. Here, we utilise GPS tracking devices and novel applications of ecological methods to develop fine-scale models of human space use relative to land cover to assess exposure to the zoonotic malariaPlasmodium knowlesi in Malaysian Borneo. Combining data with spatially explicit models of mosquito biting rates, we demonstrate the role of individual heterogeneities in local space use in disease exposure. At a community level, our data in...
Source: eLife - Category: Biomedical Science Tags: Epidemiology and Global Health Source Type: research
Reducing the burden of malaria highly depends on access to prompt and effective malaria diagnosis and treatment. The aim of this study was to identify challenges affecting prompt access to effective uncomplica...
Source: BMC Health Services Research - Category: General Medicine Authors: Tags: Research article Source Type: research
ConclusionMD influenced the pharmacokinetics of AQ and desethylamodiaquine, its major metabolite. The increase in the half-life and systemic exposure of AQ following its co-administration with MD may provide a basis for the enhanced pharmacological effect of the combination in an earlier study inPlasmodium-infected mice.
Source: European Journal of Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
Conclusions: Naturally acquired sexual stage immunity, as detected by antibodies to Pfs230 and Pfs48/45, was present in most studies analyzed. Significant between-study heterogeneity was seen, and methodological factors were a major contributor to this, and prevented further analysis of epidemiological and biological factors. This demonstrates a need for standardized protocols for conducting and reporting seroepidemiological analyses.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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