Pharmacokinetics of ADS-5102 (Amantadine) Extended  Release Capsules Administered Once Daily at Bedtime for the Treatment of Dyskinesia

ConclusionsADS-5102 can be administered once-daily qhs to achieve high amantadine plasma concentrations in the morning and throughout the day, when symptoms of dyskinesia occur.
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research