First reported case of multidrug-resistant Candida auris in Canada.

First reported case of multidrug-resistant Candida auris in Canada. Can Commun Dis Rep. 2017 Jul 06;43(7-8):150-153 Authors: Schwartz IS, Hammond GW Abstract Candida auris is a fungal pathogen that has recently emerged as a global threat to public health. It was first described in Japan in 2009 and has since been reported in 17 countries on five continents. This case report describes the first reported case of multidrug-resistant C. auris in Canada. In May 2017, a 64-year-old individual was evaluated for chronic otitis externa. Past medical history included a recent hospitalization in India for elective oral surgery that was complicated by an odontogenic brain abscess. Upon return to Canada, the individual was admitted to a hospital for neurosurgical drainage of the brain abscess and parenteral antibiotics. Early during hospitalization, the patient was identified as a carrier of carbapenem-resistant Enterobacteriaceae and was placed on contact precautions. Also early during this hospitalization, a chronic otitis media was managed with placement of a typanostomy tube with drainage of clear fluid from the ear, which continued through the admission and after discharge to a post-neurosurgical rehabilitation facility. During outpatient follow-up, swabs of the ear discharge cultured C. auris that was resistant to fluconazole and amphotericin B. There was no clinical response to ototopical antifungal therapy. Surgical evaluation for management of the otomastoid...
Source: Can Commun Dis Rep - Category: Infectious Diseases Authors: Tags: Can Commun Dis Rep Source Type: research

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Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate K2[B3O3F4OH] inhibits emerging multidrug-resistant and β-lactamase-producing opportunistic pathogens. Drug Dev Ind Pharm. 2019 Aug 16;:1-21 Authors: Maravić A, Rončević T, Krce L, Ilić N, Galić B, Čikeš Čulić V, Carev I Abstract Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate, K2[B3O3F4OH] (boroxine) was previously shown to be very effective in inhibition of several carcinoma cell lines, including the skin cancer. Here, we investigated its antimicrobial potential by targeting the multidrug-resistan...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
CONCLUSION: This study showed positive workplace culture change associated with the quality improvement intervention. Lessons learned from the implementation of this program can inform future quality improvement initiatives. PMID: 31416705 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Publication date: Available online 16 August 2019Source: Social Science &MedicineAuthor(s): Marian KrawczykAbstractHospitals remain the most common location of death in a significant number of countries, and specialist palliative care is positioned as a crucial resource for improving hospital care for those nearing end of life. Little is known, however, about a substantive aspect of this work: how hospital palliative clinicians anticipate and organize a patient's dying trajectory. In this paper I draw from a larger original ethnographic research study of palliative specialists in two Canadian hospitals. Abductive analy...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
ConclusionThis is the first multicentre report of antifungal resistance rates among candidaemia isolates in Turkey, suggesting low resistance rates in general. Due to varying rates of fluconazole resistance in C. parapsilosis SC isolates that was detected at remarkably high levels in some centres, further studies are warranted to explore the source, clonal relatedness and resistance mechanisms of the isolates.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 16 August 2019Source: Journal of Ayurveda and Integrative MedicineAuthor(s): Sushma Bagde Bhatwalkar, Prashant Shukla, Rupesh K. Srivastava, Rajesh Mondal, Rajaneesh AnupamAbstractEnvironmental disinfection greatly reduces the occurrence of nosocomial or healthcare associated infections (HCAIs) which are the major healthcare problems worldwide. In India, Ayurvedic traditional fumigation with natural plant products is used to disinfect environment. In the present study, environmental disinfection efficiency of traditional fumigation practice has been evaluated by using natural plant produc...
Source: Journal of Ayurveda and Integrative Medicine - Category: Complementary Medicine Source Type: research
Publication date: Available online 16 August 2019Source: Journal of Clinical NeuroscienceAuthor(s): Masaaki Machino, Kei Ando, Kazuyoshi Kobayashi, Masayoshi Morozumi, Satoshi Tanaka, Keigo Ito, Fumihiko Kato, Naoki Ishiguro, Shiro ImagamaAbstractA comparative study to examine the surgical outcomes of traumatic cervical myelopathy (TCM) patients was designed. The study aim was to compare the surgical outcomes between TCM and degenerative cervical myelopathy (DCM) and to characterize the preoperative symptoms and postoperative residual symptoms in TCM patients. One hundred consecutive patients with TCM (81 men, 19 women; me...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 16 August 2019Source: Clinica Chimica ActaAuthor(s): Yoshiki Nishizawa, Masakazu Miura, Shoichi Ichimura, Masaaki Inaba, Yasuo Imanishi, Masataka Shiraki, Junichi Takada, Osamu Chaki, Hiroshi Hagino, Masao Fukunaga, Saeko Fujiwara, Takami Miki, Noriko Yoshimura, Hiroaki Ohta, from the Japan Osteoporosis Society Bone Turnover Marker Investigation CommitteeAbstractWith the aging of society, the number of osteoporosis-related fractures is increasing. Prevention of osteoporosis and maintenance of the quality of life of osteoporosis patients require early diagnosis, effective treatment, and hi...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
ConclusionsThis was presumed to be a rare case of twin pregnancy by triploid embryo formation, followed by loss of an allele due to postzygotic diploidization, development of a diploid fetus, and development of another fetus from a separate embryo. Because of the existence of cases such as this one with a diploid fetus, but without a normal pregnancy coexistent with a complete hydatidiform mole, diagnosis by genetic analysis is required for prognosis.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Publication date: December 2019Source: Food Packaging and Shelf Life, Volume 22Author(s): Manokaran Vadivel, Murugesan Sankarganesh, Jeyaraj Dhaveethu Raja, Jegathalaprathaban Rajesh, Dhanuskodi Mohanasundaram, Muthukaruppan AlagarAbstractThe prime objective of the present study is to develop a biodegradable food packaging hybrid film materials from renewable sources. Polyvinyl alcohol (PVA), chitosan (CS), xylan (CC) and hydroxyapatite (nHA) were used as the sources of bio-degradable polymer and curcumin (Cur) as antioxidant agent to prepare an intelligent packaging PVA/CS/CC/nHA hybrid film (PCC) to assess the fish fresh...
Source: Food Packaging and Shelf Life - Category: Food Science Source Type: research
This study reveals the presence of a multigene defensin family in I. holocyclus with wide antimicrobial activity.
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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