Abuse-Deterrent Opioid Formulations Abuse-Deterrent Opioid Formulations

How do abuse-deterrent opioid formulations work--and are they effective? This review details the mechanisms and pharmacology of 10 abuse-deterrent formulations currently approved in the US.Anesthesiology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pharmacist Journal Article Source Type: news

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In this study we extended the range of stimulation frequencies, using also low and medium stimulation frequencies (4, 6, 8, 12, 20, 40 Hz) and studied their susceptibility to the loss of consciousness in NREM sleep (N2 and N3 stages).Effects of NREM sleep were examined in power domain with relative power (RP), and in phase domain using inter-trial phase coherence (PC) parameter. The activity in power domain was also compared to no-stimulation data. Regions displaying significant waking-NREM sleep differences were selected using non-parametric suprathreshold cluster test. For 4, 6, 20 and 40 Hz stimulation relative powe...
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research
Authors: Choi ES, Kim YI, Kang HG, Kim JH, Kim HS, Lin PP Abstract The purpose of this study is to demonstrate the surgical technique and to show the results of percutaneous cementoplasty (PC) for acetabular metastases using lateral approach under regional anesthesia. Forty-two cases underwent PC for acetabular metastases. The PC was performed using spinal anesthesia, lateral approach and fluoroscopic guidance. We assessed visual analogue scale (VAS) and revised musculoskeletal tumor society (MSTS) rating system and maximum standardized uptake value (SUVmax) of the acetabular lesion using F-18-FDG PET/CT before and...
Source: Acta Orthopaedica Belgica - Category: Orthopaedics Tags: Acta Orthop Belg Source Type: research
ConclusionUltrasound neuromodulation of a freely-moving animal is now possible using the developed lightweight and compact system to conduct a versatile set of in vivo experiments.
Source: Brain Stimulation - Category: Neurology Source Type: research
Authors: Pavlović N, Manola Š, Vražić H, Vučić M, Brusich S, Radeljić V, Zeljković I, Matasić R, Anić A, Benko I, Gavranović Ž, Zlatić Glogoški M Abstract Four thousand cardiac implantable electronic devices (CIED) are implanted yearly in Croatia with constant increase. General anesthesia and surgery carry some specific risk for the patients with implanted CIEDs. Since most of the surgical procedures are performed in institutions without reprogramming devices available, or in the periods when they are unavailable, these guidelines aim to standardize the protocol for perioperative managemen...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
Publication date: Available online 17 November 2018Source: Anaesthesia &Intensive Care MedicineAuthor(s): Michael O'Connor, C Stephanie CattlinAbstractSurvival and subsequent good neurological outcome following cardiac arrest depends on prompt diagnosis, good quality cardiopulmonary resuscitation (CPR) with minimal interruptions and rapid defibrillation, if appropriate. In the post resuscitation phase, diagnosis and treatment of the underlying cause for the arrest with avoidance of hypotension, hyperthermia, hyperoxia, hyper/hypoglycaemia and management of seizure activity confers the best chances of a successful outco...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
This study provided some pioneering ideas for encapsulating small molecule drug with poor solubility. The optimized microspheres could be chosen as an ideal candidate for the ropivacaine sustained release with its better drug adherence, lower toxicity of drug burst release and best therapeutic effect.Graphical abstract
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
This article presents a case report of a 39-yr-old woman with pain, pruritus, and a hyperpigmented area in the right dorsal infra scapular region. The diagnosis of notalgia paresthetica was established. She was successfully treated with topical anesthetics, postural corrective exercises, scapular muscle strengthening, and pectoral muscle stretching. In this context, different treatment options were reviewed. A small set of pharmacological and nonpharmacological techniques were identified. Several of these modalities belong to the physical medicine and rehabilitation field of action.
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Case Report Source Type: research
The prevalence of adult congenital heart disease (ACHD) is increasing due to advances in surgical techniques, anesthesia, and perioperative care. Imaging plays an important role, not only in the surveillance of ACHD, but also in the initial evaluation of cases that have escaped detection early in life and present with symptoms later in adulthood. In this article, we review the role of computed tomography in the comprehensive evaluation of ACHD.
Source: Radiologic Clinics of North America - Category: Radiology Authors: Source Type: research
Congenital abnormalities of the thoracic aorta encompass a variety of disorders with variable clinical manifestations ranging from asymptomatic to life threatening. A variety of imaging modalities are available for the evaluation of these anomalies with computed tomography (CT) commonly preferred due to its excellent spatial resolution and rapid acquisitions, avoiding the need of general anesthesia or even sedation. We review the embryology, imaging findings, and associations of multiple congenital thoracic aorta malformations with emphasis in the role of CT angiography in the evaluation of these pathologies.
Source: Radiologic Clinics of North America - Category: Radiology Authors: Source Type: research
ConclusionsFactors for non ‐compliance were absence of a father (P=0.01) and higher child‐anxiety (P=0.01) and, to a lesser extent, a low parent/carer education level (P=0.09). Interactive cartoons featuring dental assessment, oral health messages and modelling featured in the more popular slides.This article is protected by copyright. All rights reserved.
Source: International Journal of Paediatric Dentistry - Category: Dentistry Authors: Tags: Original Article Source Type: research
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