Abuse-Deterrent Opioid Formulations Abuse-Deterrent Opioid Formulations

How do abuse-deterrent opioid formulations work--and are they effective? This review details the mechanisms and pharmacology of 10 abuse-deterrent formulations currently approved in the US.Anesthesiology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pharmacist Journal Article Source Type: news

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Authors: Shigematsu K, Iwashita K, Mimata R, Owaki R, Totoki T, Gohara A, Okawa J, Higashi M, Yamaura K Abstract This retrospective study was aimed to investigate the association between preoperative left ventricular (LV) cardiac function and the incidence of postoperative pulmonary edema (PE) in patients undergoing carotid endarterectomy (CEA). Most patients undergoing CEA for carotid artery stenosis have concomitant heart diseases, leading to hemodynamic instability that can cause postoperative cardiac complications such as cardiac heart failure. LV diastolic function has recently been recognized as an independen...
Source: Neurologia Medico-Chirurgica - Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research
Authors: Fusco P, Volpe D, De Paolis V, De Sanctis F, Scimia P, Marinangeli F, Petrucci E Abstract PMID: 31106556 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Authors: Bojaxhi E, Lumermann LA, Mazer LS, Howe BL, Ortiguera CJ, Clendenen SR Abstract BACKGROUND: Interscalene brachial plexus block is a commonly employed regional anesthetic technique for total shoulder arthroplasty, and a continuous catheter is often placed to extend the analgesic benefit of the block. As periarticular local infiltration analgesia (LIA) for total joint arthroplasty is a re-emerging trend, we evaluated the analgesic efficacy of continuous interscalene block (CISB) compared to single-shot interscalene block (SSISB) with LIA. METHODS: We conducted a retrospective review of 130 consecutive pa...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Authors: Bastian K, Buehler PK, Slizyte D, Rüst CA, Toft K, Studer W, Lecheler L, Aguirre J, Siegemund M, Hollinger A Abstract BACKGROUND: Data from patient questionnaires reveal that the intensity of postoperative pain is widely underestimated. Insufficient pain control may contribute to impaired short- and long-term outcome. Preoperative administration of methadone might potentially improve postoperative pain control due to its long pharmacological half-life. METHODS: The aim of this study was to evaluate the effect of a single dose of methadone administered at anesthesia induction on postoperative analg...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
This study examined the impact of different doses of dexamethasone, given to reduce postoperative nausea and vomiting (PONV) after elective colonic resection for cancer, on the postoperative Glasgow Prognostic Score (poGPS) and morbidity.MethodsPatients from a single centre were included if they underwent potentially curative resection of colonic cancer from 2008 to 2017 (n = 480). Patients received no dexamethasone (209, 44%), or either 4 mg (166, 35%), or 8 mg (105, 21%), intravenously during anaesthesia, at the discretion of the anaesthetist. The postoperative Glasgow Prognostic Score (poGPS) on day 3 and 4, and...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionCO2 absorption rates, anesthesiologists’ ability to maintain adequate etCO2 and post-operative shoulder pain did not differ based on insufflation system type or IAP. Surgeons’ rating of visualization of the operative field was significantly improved when using the valveless over the standard insufflation system.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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Source: Johns Hopkins University and Health Systems Archive - Category: Nursing Source Type: news
Anogenital warts are caused by human papillomavirus types 6 and 11. They are rare in children, and treatment is difficult since conventional treatments are generally painful and require the patient to be anesthetized. Topical diphenylcyclopropenone (DPCP) is a contact immunotherapy used for treatments of recalcitrant warts and alopecia areata. We herein report 3 cases of anogenital warts in children successfully treated with topical DPCP. Our results suggest that topical DPCP may be a valuable option for the treatment of anogenital warts in children who have difficulty with painful destructive therapy.Case Rep Dermatol 2019;11:123 –129
Source: Case Reports in Dermatology - Category: Dermatology Source Type: research
Publication date: Available online 21 May 2019Source: Brazilian Journal of Anesthesiology (English Edition)Author(s): Laurent Becuwe, Jean-Christian Sleth, Yann-Erwan Favennec, Gilles Candelier
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
ConclusionIntrathecal (S)-(+)-Ketoprofen caused dose-dependent neurohistopathological changes in rats on days 3 and 7 after injection, suggesting that (S)-(+)-Ketoprofen should not be intrathecally administered.ResumoJustificativa e objetivosA administração intratecal de anti-inflamatórios não esteroides é mais eficaz no tratamento da dor pós-operatória. A Anti-inflamatórios não esteroides, como o (S)-(+)-cetoprofeno, pode ser eficaz em doses intratecais inferiores às parenterais; a segurança pré-clínica relativa à possí...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
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