NDRG1 disruption alleviates cisplatin/sodium glycididazole-induced DNA damage response and apoptosis in ERCC1-defective lung cancer cells.

CONCLUSION: NDRG1 is an important modulator linking DNA damage response and hypoxia-related cellular stress response during the development of drug resistance to cisplatin/CMNa in lung cancer. Targeting both NDRG1 and ERCC1 may be a viable strategy for overcoming drug resistance in cancer therapy, and has significant clinical implications.
PMID: 29768183 [PubMed - as supplied by publisher]

Source: The International Journal of Biochemistry and Cell Biology - May 13, 2018 Category: Biochemistry Authors: He L, Liu K, Wang X, Chen H, Zhou J, Wu X, Liu T, Yang Y, Yang X, Cui D, Song G, Lei J, Wang J Tags: Int J Biochem Cell Biol Source Type: research