Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative

The objective of this study was to evaluate whether polygenic risk scores (PRS) for common cancers are associated with multiple phenotypes in a phenome-wide association study (PheWAS) conducted in 28,260 unrelated, genotyped patients of recent European ancestry who consented to participate in the Michigan Genomics Initiative, a longitudinal biorepository effort within Michigan Medicine.

Source: The American Journal of Human Genetics - May 17, 2018 Category: Genetics & Stem Cells Authors: Lars G. Fritsche, Stephen B. Gruber, Zhenke Wu, Ellen M. Schmidt, Matthew Zawistowski, Stephanie E. Moser, Victoria M. Blanc, Chad M. Brummett, Sachin Kheterpal, Gon çalo R. Abecasis, Bhramar Mukherjee Tags: Article Source Type: research