Universal pneumococcal vaccination provides marked indirect beneficial effects through herd immunity

Acta Paediatrica, EarlyView.
Source: Acta Paediatrica - Category: Pediatrics Authors: Source Type: research

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Conclusions: The incidence and mortality rate of community-onset severe bacterial infections, except for S. aureus infection, have decreased in France. N. meningitidis and S. pneumoniae continue to account for many infections, which indicates the need for better vaccination coverage and spectrum.
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Online Clinical Investigations Source Type: research
Worldwide use of pneumococcal conjugate vaccines (PCVs) had reduced the incidence of pneumonia and invasive pneumococcal disease (IPD) in children.1,2 Despite increasing vaccine coverage and a reduction in the prevalence of IPD, Streptococcus pneumoniae remains a significant cause of non-Shiga toxin-producing Escherichia coli hemolytic uremic syndrome (HUS) in children.3 HUS is characterized by the presence of the clinical triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Editorial Source Type: research
CONCLUSIONS: This post-vaccination study showed that less than one-fifth of the AIRD patients are adequately protected against pneumococcal infection, although the immunization programme had been implemented in more than half of the study population. Development of improved vaccination strategies is required to achieve a higher immunization coverage rate and more efficient lasting antibody response. PMID: 32468899 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - Category: Rheumatology Authors: Tags: Scand J Rheumatol Source Type: research
Celiac disease (CD), triggered by the ingestion of gluten, occurs in people genetically predisposed to develop the chronic autoimmune condition. During the past few decades, doctors have learned much about how the disease develops, including genetic and other risk factors. However, results from studies on whether people with CD have an increased risk of premature death linked to the condition have been mixed. A recent study shows a small but statistically significant increased mortality rate. Celiac disease can affect the entire body Until recently, CD was considered a mainly pediatric gastrointestinal disorder, associated...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Allergies Autoimmune diseases Source Type: blogs
Streptococcus pneumoniae is an important cause of severe bacterial infections in young children and the elderly (Valenzuela et al., 2009). In Cuba, high rates of nasopharyngeal colonization have been reported in children
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Conditions:   S. Pneumoniae;   Pneumococcal Conjugate Vaccine Intervention:   Biological: Prevenar 7 and Prevenar 13 Sponsors:   University Hospital Southampton NHS Foundation Trust;   Solent NHS Trust Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
is Surveillance Network In West Africa Abstract Despite the implementation of effective conjugate vaccines against the three main bacterial pathogens that cause meningitis, Streptococcus pneumoniae, Haemophilus influenzae type b (Hib), and Neisseria meningitidis serogroup A, the burden of meningitis in West Africa remains high. The relative importance of other bacterial, viral, and parasitic pathogens in central nervous system infections is poorly characterized. Cerebrospinal fluid (CSF) specimens were collected from children younger than 5 years with suspected meningitis presenting at pediatric teaching hospitals...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
Condition:   S. Pneumoniae, Pneumococcal Conjugate Vaccine Intervention:   Biological: Prevenar 7 and Prevenar 13 Sponsors:   University Hospital Southampton NHS Foundation Trust;   Solent NHS Trust Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/ Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitoch...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conditions:   Pneumococcal Immunisation;   Diphtheria Immunisation;   Tetanus Immunisation;   Pertussis Immunisation;   Hepatitis B Immunisation;   Haemophilus Influenzae Type b Immunisation;   Polio Immunisation;   Measles Immunisation;   Rubella Immunisation;   Varicella Immunisation;   Mumps Immunisation Interventions:   Biological: SP0202-IIb Pneumococcal Conjugate Vaccine formulation 1;   Biological: SP0202-VI Pneumococcal Conjugate Vaccine formulation 2;   Biological: SP0202...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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