Fluctuating CSF hypocretin-1 levels in mild brain trauma-induced Kleine-Levin syndrome
Kleine-Levin syndrome (KLS) is a rare sleep disorder, mainly affecting adolescent boys, and is characterized by recurrent hypersomnia combined with cognitive, mood, and/or behavioral disturbances [1]. It typically follows various precipitating factors such as infection, alcohol-drinking, and mental and physical stress [1]. Although the precise pathophysiology of KLS remains unclear, several functional neuroimaging studies have shown hypoperfusion in the hypothalamus, thalamus, caudate nucleus, and associative cortical areas during symptomatic and/or asymptomatic periods in patients with KLS [2].
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Maho Usuda, Minori Kodaira, Yuka Ogawa, Takashi Kanbayashi, Shin Yanagisawa, Yoshiki Sekijima Tags: Letter to the Editor Source Type: research
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