Fluctuating CSF hypocretin-1 levels in mild brain trauma-induced Kleine-Levin syndrome

Kleine-Levin syndrome (KLS) is a rare sleep disorder, mainly affecting adolescent boys, and is characterized by recurrent hypersomnia combined with cognitive, mood, and/or behavioral disturbances [1]. It typically follows various precipitating factors such as infection, alcohol-drinking, and mental and physical stress [1]. Although the precise pathophysiology of KLS remains unclear, several functional neuroimaging studies have shown hypoperfusion in the hypothalamus, thalamus, caudate nucleus, and associative cortical areas during symptomatic and/or asymptomatic periods in patients with KLS [2].
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research