Protective effects of heme oxygenase 1 during ischemia-reperfusion injury: Hepatocytes or non-parenchymal cells?

Hepatic ischemia-reperfusion injury (IRI) remains an important issue in clinical procedures such as liver resection and organ transplantation and in the context of trauma and shock. Hepatic IRI may lead to poor early graft function and even acute or chronic organ rejection and may affect long-term patient/graft survival after liver transplantation. Although hepatic IRI is one of the major causes of morbidity and mortality in liver surgery, there are currently no effective therapeutic strategies to protect the liver from IRI.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research