Chronotype influences response to antidepressant chronotherapeutics in bipolar patients.

Chronotype influences response to antidepressant chronotherapeutics in bipolar patients. Chronobiol Int. 2018 May 15;:1-7 Authors: Dallaspezia S, Suzuki M, Clara L, Colombo C, Benedetti F Abstract Patient diurnal mood fluctuation, sleep characteristics and factors affecting sleep homeostasis predict antidepressant response to the combination of total sleep deprivation and light therapy (TSD + LT). In order to study if chronotype could influence response to TSD+LT, we considered 194 bipolar depressed patients. Severity of depression was rated with Hamilton Depression Rating Scale; perceived mood levels were assessed by a self-administered 10-cm visual analogue scale and chronotype was assessed using the Mornigness-Eveningness Questionnaire. More than 60% of patients resulted responders to treatment with chronotype influencing the antidepressant response with evening type subjects showing higher response rates. PMID: 29764214 [PubMed - as supplied by publisher]
Source: Chronobiology International - Category: Biology Authors: Tags: Chronobiol Int Source Type: research