Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence

In this report, Lowry and colleagues found that loss of MECP2 has a more profound effect as pluripotent stem cells are terminally differentiated toward neurons. The loss of MECP2 leads to induction of P53 protein and subsequent senescence pathways including an SASP gene program, which appears to be a cause of diminished dendritic branching in Rett neurons.
Source: Stem Cell Reports - Category: Stem Cells Source Type: research