Human Induced Pluripotent Stem Cell-Derived Cardiac Cell Sheets Expressing Genetically Encoded Voltage Indicator for Pharmacological and Arrhythmia Studies

In conclusion, ArcLight mapping of hiPSC-CCSs provides a powerful tool for drug testing and arrhythmia investigation. Graphical abstract Teaser Shaheen and Shiti et al. combine hiPSC-CMs, two-dimensional cardiac tissue models, and optical mapping of a genetically encoded voltage indicator (ArcLight) to enable both short-term and repeated tissue electrophysiological phenotyping (over weeks). This allowed tracking of electrophysiological tissue remodeling over time; drug effects on conduction, repolarization, and pro-arrhythmia; and investigation of arrhythmia mechanisms and treatments.
Source: Stem Cell Reports - Category: Stem Cells Source Type: research