Aggregation kinetics of the A β1-40 peptide monitored by NMR.

Aggregation kinetics of the Aβ1-40 peptide monitored by NMR.
Chem Commun (Camb). 2018 May 16;:
Authors: Bellomo G, Bologna S, Gonnelli L, Ravera E, Fragai M, Lelli M, Luchinat C
Abstract
The aggregation of Aβ1-40 was monitored by solution NMR, which showed a trend complementary to the one observed by ThT-fluorescence. The NMR data support a kinetic model where Aβ1-40 initially aggregates with the reversible formation of oligomeric species, which then irreversibly convert into fibrils.
PMID: 29767190 [PubMed - as supplied by publisher]

Source: Chemical Communications - May 16, 2018 Category: Chemistry Authors: Bellomo G, Bologna S, Gonnelli L, Ravera E, Fragai M, Lelli M, Luchinat C Tags: Chem Commun (Camb) Source Type: research