Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow.

We report an acridium-based organic photocatalyst as an efficient replacement for iridium-based photocatalysts to oxidise boronic acid derivatives by a single electron process. Furthermore, we applied the developed catalytic system to the synthesis of four active pharmaceutical ingredients (APIs). A straightforward scale up approach using continuous flow photoreactors is also reported affording gram an hour throughput.
PMID: 29767201 [PubMed - as supplied by publisher]

Source: Chemical Communications - May 16, 2018 Category: Chemistry Authors: Lima F, Grunenberg L, Rahman HBA, Labes R, Sedelmeier J, Ley SV Tags: Chem Commun (Camb) Source Type: research