Shorter Time to Pregnancy With Increasing Preconception Carotene Concentrations Among Women With 1 to 2 Previous Pregnancy Losses.

Shorter Time to Pregnancy With Increasing Preconception Carotene Concentrations Among Women With 1 to 2 Previous Pregnancy Losses. Am J Epidemiol. 2018 May 14;: Authors: Kim K, Schisterman EF, Silver RM, Wilcox BD, Lynch AM, Perkins NJ, Browne RW, Lesher LL, Stanford JB, Ye A, Wactawski-Wende J, Mumford SL Abstract Although maternal nutrition may impact fecundity, associations between preconception micronutrients and time to pregnancy (TTP) has not been examined. We assessed the relationship between preconception fat-soluble micronutrient concentrations and TTP among women with 1-2 prior pregnancy losses. This is a prospective cohort study of 1,228 women set in the EAGeR Trial (US, 2007-2011), which assessed the effect of preconception-initiated daily low dose aspirin on reproductive outcomes. We measured preconception zeaxanthin, cryptoxanthin, lycopene, α- and β-carotene, and α- and γ-tocopherol in serum. We used discrete Cox regression models, accounting for left truncation and right censoring, to calculate fecundability odds ratios (FOR) and 95% confidence intervals (CI). Models were adjusted for age, body mass index, race, smoking, alcohol, physical activity, income, vitamin use, cholesterol, treatment arm, and study site. Serum α-carotene levels (FOR = 1.17, 95% CI: 1.00, 1.36, per log unit [μg/dL] increase), as well as concentrations above versus below the US average (2.92 μg/dL) were associated with shorter TTP (FOR...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research