14. Clinical mate-pair sequencing reveals complex genomic rearrangements in B-lymphoblastic leukemia/lymphoma (B-ALL)

B-lymphoblastic leukemia/lymphoma (B-ALL) is an aggressive hematologic malignancy currently subcategorized into multiple genetic subtypes based on the identification of recurrent acquired chromosome abnormalities. Identification and accurate characterization of these multiple and varied chromosome abnormalities is essential to the diagnosis, prognosis and emerging predictive therapeutic targets in B-ALL patients and is typically achieved through standard karyotyping and fluorescence in situ hybridization (FISH) testing.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research