Subtrochanteric and diaphyseal femoral fractures in hypophosphatasia —not atypical at all

ConclusionsIncreased risk for subtrochanteric and diaphyseal femoral fractures in HPP appears to result from both compromised bone metabolism as well as disease-associated bone deformities. In severe HPP, generous screening for such fractures seems advisable. Bisphosphonates and Hypovitaminosis D should be avoided. Healing is compromised and requires mindful consideration of both pharmacological and surgical options.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research