Robert Jarvik: An Innovator with Heart

Robert Jarvik, MD, remembers Dec. 2, 1982, as vividly as if it were last week. He was 36 at the time and a device he designed, the Jarvik 7 artificial heart, was about to be implanted into a human patient for the first time. That patient, a retired dentist named Barney Clark, had been at the University of Utah Hospital in Salt Lake City for about a week, and his medical team, lead by William DeVries, MD, planned to put off the surgery just a little while longer in hopes of getting Clark as strong as possible for the operation. But Clark wasn't getting stronger. Robert Jarvik, MD, will receive the MDEA Lifetime Achievement Award during a special ceremony at MD&M East in New York City on June 12, 2018.  "He deteriorated rather fast and Dr. DeVries did not think he would live through the night, so they scheduled the surgery for the soonest they could get it done, which was something that began around 10 at night," Jarvik told MD+DI. "There was a very, very large snow storm that hit just about that time." In what seemed like no time at all, the streets of Salt Lake City had accumulated between six inches and a foot of snow. "The University hospital is uphill from the city so I remember distinctly trying to get there and wondering if I was going to miss it because of the snow," Jarvik said. "But I did get there on time and most of the team was there and it became a very intense scene. You can imagine, the middle of the night a...
Source: MDDI - Category: Medical Devices Authors: Tags: MD & M East (New York) Cardiovascular Design Source Type: news

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Publication date: 23–29 March 2019Source: The Lancet, Volume 393, Issue 10177Author(s): Feng J He, Graham A MacGregor
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: 23–29 March 2019Source: The Lancet, Volume 393, Issue 10177Author(s): Luke N Allen
Source: The Lancet - Category: General Medicine Source Type: research
This study is the first to identify a Korean MCPyV strain in whole-blood samples from Korean patients with kidney disease and healthy individuals.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
This study was funded in part by the National Institutes of Health (NIH) through MD Anderson's Cancer Center Support Grant ( CA016672).
Source: The Lancet Haematology - Category: Hematology Source Type: research
Publication date: Available online 22 March 2019Source: Pharmacological ResearchAuthor(s): Saeideh Hajighasemi, Armita Mahdavi Gorabi, Vanessa Bianconi, Matteo Pirro, Maciej Banach, Hossein Ahmadi tafti, Željko Reiner, Amirhossein SahebkarAbstractFamilial hypercholesterolemia (FH) is a genetic autosomal dominant disorder caused by an impaired receptor-mediated low-density lipoprotein (LDL) removal from the circulation, mainly due to disruptive autosomal co-dominant mutations in the LDL receptor (LDLr) gene, but also less frequently in the apolipoprotein B100 (APOB) and proprotein convertase subtilisin/kexin type 9 (PCSK9)...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
In conclusion, this study identifies that administration of RTX can inhibit pressure overload-induced cardiac remodeling and dysfunction in mice, and suggest that RTX may be a promising drug for treating hypertrophic disease.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Discussion: Incomplete septal cirrhosis is an uncommon cause of non-cirrhotic portal hypertension. Its definition is not well known, morphological and pathophysiological. We have not found published cases of post-RT ascites secondary to this pathology, described as possibly associated with drugs, immune alterations, infections, hypercoagulability and genetic predisposition. PMID: 30897191 [PubMed - as supplied by publisher]
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
Ventricular assist devices (VADs) are an important technological development for patients with end-stage heart failure, and approximately 50% of these patients require various additional cardiac procedures. Here we presente the case of a patient suffering from severe aortic insufficiency, aortic root dilatation, and an ascending aortic aneurysm with end-stage decompensated heart failure. We performed the Bentall procedure combined with a left VAD implantation during the same session. The postoperative period was uneventful for this patient, and he was discharged on the 32nd postoperative day. The heart failure sym...
Source: Brazilian Journal of Cardiovascular Surgery - Category: Cardiology Source Type: research
Publication date: Available online 23 March 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Hiroshi Ureshino, Kazuharu Kamachi, Shinya KimuraAbstractMogamulizumab, a defucosylated humanized monoclonal antibody against C–C chemokine receptor 4 (CCR4), has been approved for the treatment of relapsed adult T-cell leukemia/lymphoma (ATL). Compared with conventional chemotherapy, mogamulizumab monotherapy displayed more effecacy in relapsed ATL making mogamulizumab a promising therapeutic agent. However, mogamulizumab could increase graft-versus-host disease, resulting in poor survival outcome in allogenic st...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Authors: Belachew N, Jerkic S, Michel F, Schubert R, Zielen S, Rosewich M Abstract INTRODUCTION:  Bronchiolitis obliterans (BO) is a rare and severe pulmonary disease which can occur due to airway infection or as a result of stem cell or lung transplantation. Our goal was to study the lung function and airway inflammation among BO patients. Furthermore, we examined the potential of the lung clearance index (LCI) for BO diagnostics among that group. METHODS:  16 BO patients (age: 16.7; 9.6 - 25.3 years) and 17 healthy controls (age: 16.6; 7.6 - 25.0 years) participated in the study. Lung functi...
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
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