Diagnostic value of myocardial deformation pattern in children with noncompaction cardiomyopathy

We describe left ventricular (LV) deformation patterns in children with NCC, with the goal of identifying a potential diagnostic pattern. We prospectively enrolled 30 children with NCC (47% male; mean age 7.2  years) and 30 age- and gender-matched controls. Extent and severity of non compaction in each segment were evaluated in LV 16-segment model. Regional (base, mid and apex) and segmental (16 segments) longitudinal strain (LS), circumferential strain (CS) and radial strain (RS) were measured using sp eckle tracking echocardiography. In all patients with NCC, regional and segmental CS and RS at the apex were significantly decreased compared to controls (CS apex: − 19.2 ± 5.4% vs. − 30.2 ± 6.9%, p <  0.001/RS apex: 23.5 ± 8.6% vs. 44.1 ± 14.5%, p <  0.001). Thirty percent (9/30) of patients had an EF <  50%. In these patients, there was additional decrease in CS in basal segments and in LS in basal, mid-cavity and apical segments (CS base: − 16.4 ± 4.7% vs. − 24.6 ± 3.9%, p <  0.001/LS (average all LV segments): − 13.9 ± 3.1% vs. − 20.7 ± 4.7%, p <  0.001). A cut-off value of CS at the apex of − 24.5% was a strong differentiating feature between patients with NCC and EF >  50% and controls (sensitivity: 87%, specificity 79%, AUC 0.88, p <  0.001). Children with NCC exhibit a deformation pattern characterized by decreased apical circumferential strain, which m...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research