Drug Combo May Help Lower Danger After Mini-Stroke
The American Stroke Association reports that more than one-third of U.S. adults have had a transient ischemic attack/mini-stroke.
AbstractMesenchymal stromal cells (MSCs) can differentiate into multiple tissues. Preclinical studies have shown that MSC-based therapy is a potential new treatment approach for ischemic stroke. These results support the urgent need for further studies of MSC transplantation in the treatment of ischemic stroke in humans. Here, we develop a prospective, randomized, controlled, observer-blinded phase II trial to assess the clinical safety, feasibility, and therapeutic mechanisms of allogenic bone marrow-derived MSCs (BM-MSCs) by intrathecal infusion in the treatment of patients with cerebral infarction within the middle cere...
The aim of this study was to examine predictors of mortality in patients 5 years after ischemic stroke, focusing on cognitive impairment, vulnerability, and vascular risk factors assessed at 6 months post stroke.
Tocovid is a new combination of tocotrienols and tocopherol, both of which are neuroprotective agents for preventing cerebral infarction in mice. However, the effects of tocovid on anti-inflammation in ischemic model remain elusive. In the present study, we assessed the effects of Tocovid pretreatment on anti-inflammatory effects after transient middle cerebral occlusion (tMCAO) in mice.
Conclusions: CSCs and PSCs achieved similar overall care quality for patients with acute ischemic stroke. CSCs exceeded PSCs in timely acute reperfusion therapy for emergency department admissions, whereas PSCs had lower risk-adjusted in-hospital mortality. This information may be important for acute stroke triage and targeted quality improvement.
Conclusions Despite its multicenter design, the WAKE-UP study has demonstrated a high level of homogeneity amongst raters in interpreting the various imaging criteria for patient randomization, including the novel criterion of DWI-FLAIR mismatch. Systematic image training increased the confidence of investigators in applying imaging criteria.
Conclusions The detection of acute ischemic stroke is improved by changing the display monitor from the gray scale to the yellow scale. From the perspective of color psychology, yellow is associated with higher arousal, cheerfulness, confidence, creativity, and excitement. Therefore, the yellow scale may be suitable for a medical imaging display.
Latest results from a large registry of patients with transient ischemic attack or minor stroke suggest that new strategies for further risk reduction are needed in this population.Medscape Medical News
Authors: Funaki T, Takahashi JC, Miyamoto S Abstract In this article, the authors review the literature related to long-term outcome of pediatric moyamoya disease, focusing on late cerebrovascular events and social outcome of pediatric patients once they reach adulthood. Late-onset de novo hemorrhage is rare but more serious than recurrence of ischemic stroke. Long-term follow-up data on Asian populations suggest that the incidence of de novo hemorrhage might increase at age 20 or later, even more than 10 years after bypass surgery. Social adaptation difficulty, possibly related to cognitive impairment caused by fr...
I am pleased to provide Professor Naylor with the information requested in his letter to the Editor.1 Perhaps he is guilty of a lack of follow-up, as his discussion of said manuscript has been published in the Journal of Vascular Surgery along with our article. In this natural history study of clearly asymptomatic patients, we found (mean follow-up of 5 years) an approximate twofold increase (P = .003) in transient ischemic attack (TIA) or stroke risk for patients with ≥90% vs 70% to 89% stenosis as assessed by generally accepted duplex ultrasound criteria.
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