GSE98974 Adult CNS Myelin Enhances Axonal Outgrowth From Neural Stem Cells

Contributors : Gunnar Poplawski ; Richard Lie ; Matt Hunt ; Hiromi Kumamaru ; Riki Kawaguchi ; Paul Lu ; Michael Schaefer ; Grace Woodruff ; Jacob Robinson ; Jeniffer Dulin ; Cedric Geoffroy ; Lutz Mezel ; Binhai Zheng ; Giovanni Coppola ; Mark TuszynskiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe growth of neural stem cells is strongly enhanced on myelin in vitro and in vivo. To identify the mechanisms associated with this phenome, we compared RNA expression from mouse E12 derived spinal cord cells on stimulation substrates (laminin and myelin) to permissive substrates (PDL). We identified Negr1 as mediator of the stimulatory effects of myelin.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research