GSE100955 Genome-wide maps of Tet1 binding in [WT, Tet1-Flag] and [Dnmt3a-/-, Tet1-Flag] J1 ES cells

Contributors : Xueqiu Lin ; Tianpeng Gu ; Wei Li ; Margaret A GoodellSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusIn order to assess Tet1 binding, we first generated a Flag tagged Tet1 ES cells and then knocked out Dnmt3a in the [WT, Tet1-Flag] cells. By Tet1 ChIP and Flag ChIP, we showed that Tet1 binding was complementary to Dnmt3a. And Tet1 binding was not affected or slightly increased at majority of its targets.

Source: GEO: Gene Expression Omnibus - May 16, 2018 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research