GSE114502 Altered mRNA splicing by mutant p53 activates oncogenic RAS in pancreatic cancer

Contributors : Luisa F Escobar-Hoyos ; Alex Penson ; Robert K Bradley ; Omar Abdel-Wahab ; Steven D LeachSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusIntegrating transcriptomic analyses of both clinical PDAC and PDAC models, we identified that the most common neomorphic TP53 mutation (p53R175H) rewires RNA splicing promoting transcriptome-wide retention of cassette exons bearing cytosine(C)-rich sequences.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research