MicroRNA-495 inhibits the high glucose-induced inflammation, differentiation and extracellular matrix accumulation of cardiac fibroblasts through downregulation of NOD1.
Conclusion: Upregulation of miR-495 ameliorates the high glucose-induced inflammatory, cell differentiation and extracellular matrix accumulation of human CFs by modulating both the NF-κB and TGF-β1/Smad signaling pathways through downregulation of NOD1 expression. These results provide further evidence for the protective effect of miR-495 overexpression in cases of high glucose-induced cardiac fibrosis.
PMID: 29760746 [PubMed - in process]
Source: Cellular and Molecular Biology Letters - Category: Biochemistry Authors: Wang X, Jin H, Jiang S, Xu Y Tags: Cell Mol Biol Lett Source Type: research