The RNA binding protein Ars2 supports hematopoiesis at multiple levels

Arsenic resistance protein 2 (Ars2) is an essential, highly conserved protein with mammals sharing more than 98% amino acid identity [1]. Ars2 was initially described as a modulator of arsenic sensitivity in a cDNA screen [2]; subsequent analysis determined that the ability of Ars2 to modulate arsenic sensitivity likely resulted from a dominant-negative effect of the partial cDNA sequence used in the screen [3]. Full length Ars2 did not impart arsenic resistance, but rather was found to be a component of the 5 ’-7-methylguanosine (7mG) cap binding complex (CBC) that coordinated RNA polymerase II (RNAPII) transcription with nuclear RNA processing and export [3-9].

Source: Experimental Hematology - May 15, 2018 Category: Hematology Authors: Seerat Elahi, Shawn M. Egan, G. Aaron Holling, Rachel L. Kandefer, Michael J. Nemeth, Scott H. Olejniczak Source Type: research