Lower Plasma Klotho Concentrations Are Associated with Vascular Dementia but Not Late-Onset Alzheimer ’s Disease

Conclusion: In a sample of elderly individuals, we found a significant association between low plasma Klotho levels and VD, but not LOAD. This finding suggests that, although these 2 forms of dementia might overlap, some physiopathological mechanisms related to VD and LOAD remain distinct.Gerontology
Source: Gerontology - Category: Geriatrics Source Type: research

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ConclusionThese findings suggest that LTP-like cortical plasticity may represent a neurophysiological surrogate of memory in AD patients by evaluating the weight of pathological changes responsible for cognitive dysfunction.
Source: Brain Stimulation - Category: Neurology Source Type: research
Publication date: Available online 20 October 2018Source: Trends in Pharmacological SciencesAuthor(s): Stefano L. Sensi, Alberto Granzotto, Mariacristina Siotto, Rosanna SquittiAlzheimer’s disease (AD) is one of the most common forms of dementia. Despite a wealth of knowledge on the molecular mechanisms involved in AD, current treatments have mainly focused on targeting amyloid β (Aβ) production, but have failed to show significant effects and efficacy. Therefore, a critical reconsideration of the multifactorial nature of the disease is needed. AD is a complex multifactorial disorder in which, along with A&...
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
ConclusionIn this population, there were no differences in appropriate shocks or all-cause mortality in the two groups.ResumoIntrodução e objectivoO benefício do desfibrilhador implantável está bem demonstrado nos doentes com cardiopatia isquémica. No entanto, a evidência deste benefício é menos robusta em doentes com cardiopatia não isquémica. Pretendeu-se determinar se os doentes com cardiopatia não isquémica apresentavam a mesma incidência de choque apropriado e mortalidade total, comparativamente àqueles com cardiopat...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
In this report, we propose that the molecular mechanisms of beneficial actions of CR should be classified and discussed according to whether they operate under rich or insufficient energy resource conditions. Future studies of the molecular mechanisms of the beneficial actions of CR should also consider the extent to which the signals/factors involved contribute to the anti-oxidative, anti-inflammatory, anti-tumor and other CR actions in each tissue or organ, and thereby lead to anti-aging and prolongevity. RNA Interference of ATP Synthase Subunits Slows Aging in Nematodes https://www.fightaging.org/archives/...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 20 October 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Samantha N. Cobos, Seth A. Bennett, Mariana P. TorrenteAbstractEvery year, neurodegenerative disorders take more than 5000 lives in the US alone. Cures have not yet been found for many of the multitude of neuropathies. The majority of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Parkinson's disease (PD) cases have no known genetic basis. Thus, it is evident that contemporary genetic approaches have failed to explain the etiology or etiologies of ALS/FTD and PD. Recen...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Long time readers know that I often write about exercise and fitness.  Over the past 3 years I have written often about Orange Theory Fitness.  OTF focuses on high intensity interval training (cardio) complemented by strength work.  Working out regularly makes me feel better in many ways, and I would do it for a variety of reason, but this new article adds even more fuel to my OTF fire.  Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing.   The article is free.  CNN has a great article explaining the study – ...
Source: DB's Medical Rants - Category: Internal Medicine Authors: Tags: Medical Rants Source Type: blogs
Research on changes in cognitive function, β-amyloid peptide and neurotrophic factor in stroke patients. Eur Rev Med Pharmacol Sci. 2018 Oct;22(19):6448-6455 Authors: Chen HG, Wang M, Jiao AH, Tang GT, Zhu W, Zou P, Li T, Cui GQ, Gong PY Abstract OBJECTIVE: To investigate the changes as well as the related mechanism in cognitive function and levels of serum β-amyloid peptide (Aβ) and brain-derived neurotrophic factor (BDNF) in stroke patients. PATIENTS AND METHODS: A total of 30 patients with acute stroke treated in our hospital from June 2015 to September 2016 were selected as strok...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Teleneurology is the new and vastly expanding practice of neurology involving the use of technology and/or video chat to improve access to services. With an ever-increasing aging population there is and will continue to be a shortage of neurologists in the United States. Teleneurology has increased patient access to neurologists especially in rural areas but also in urban and suburban areas. Practicing as a teleneurologist for the last two years I can log on to secure video chats compliant with the Health Insurance Portability and Accountability Act of 1996 (HIPAA). I see patients in Florida, New Hampshire, North Carolina,...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Mobile health Neurology Source Type: blogs
(Natural News) Cranberry juice, which is full of antioxidants, demonstrates various health benefits and it is often used to prevent age-related brain decline. According to a study, cranberry extract (CBE) may even help treat Alzheimer’s disease. A natural part of life, aging is often linked to the accumulation of damages “at the molecular, cellular, and organ levels.” Damage...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
In conclusion, documentation is important, a critical part of advocacy and the development process at the larger scale. It isn't just words, but rather a vital structural flow of information from one part of the larger community to another, necessary to sustain progress in any complex field. We would all do well to remember this - and to see that building this documentation is an activity in which we can all pitch in to help. Evidence Suggests that, at Least in Earlier Stages, Alzheimer's Disease Blocks Rather than Destroys Memories https://www.fightaging.org/archives/2017/07/evidence-suggests-that-at-least-in-ea...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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