Lower Plasma Klotho Concentrations Are Associated with Vascular Dementia but Not Late-Onset Alzheimer ’s Disease
Conclusion: In a sample of elderly individuals, we found a significant association between low plasma Klotho levels and VD, but not LOAD. This finding suggests that, although these 2 forms of dementia might overlap, some physiopathological mechanisms related to VD and LOAD remain distinct.Gerontology
THE FIRST human trials of a ground-breaking drug shown to repair DNA damage that contributes to Alzheimer ’s disease will be launched this week, in a move scientists hope could lead to a cure. The study, being launched in the UK, and hospitals in France and Spain, will, for the first time, see the neuro-degenerative condition treated with an agent which acts as a DNA repair kit to restore memory and r everse behavioural changes such as aggression and social avoidance.
DISCUSSION: PET can evaluate amyloid expansion from cortex to subcortex. Using striatal signal as a marker of advanced amyloidosis may increase predictive power in Alzheimer's dementia research. PMID: 29792874 [PubMed - as supplied by publisher]
DISCUSSION: Distinct classes of cognitive trajectories were associated with risk and protective factors of AD. These associations support the notion that the identified cognitive trajectories reflect different risk for AD that may be useful for selecting high-risk individuals for intervention trials. PMID: 29792873 [PubMed - as supplied by publisher]
DISCUSSION: GBA variants are of great clinical relevance for the development of dementia in Parkinson's disease, especially due to the relatively higher frequency of these alleles compared with other risk alleles. PMID: 29792872 [PubMed - as supplied by publisher]
DISCUSSION: White matter hyperintensities are associated with an increased risk of all-dementia and Alzheimer's disease in the general population. However, studies are warranted to further determine the role of markers of cerebral small vessel disease in dementia. PMID: 29792871 [PubMed - as supplied by publisher]
DISCUSSION: SNP effects on erythrocyte CR1 likely underlie the association of CR1 polymorphisms with AD risk. PMID: 29792870 [PubMed - as supplied by publisher]
Authors: Chieffo A, Buchanan GL, Mehilli J, Capodanno D, Kunadian V, Petronio AS, Mikhail GW, Capranzano P, Gonzal N, Karam N, Manzo-Silberman S, Schüpke S, Byrne RA, Capretti G, Appelman Y, Morice MC, Presbitero P, Radu M, Mauri J Abstract Several expert documents on sex-based differences in interventional outcomes are now available, however this is the first position paper from the EAPCI Women Committee discussing the potential influence of sex in the percutaneous treatment of coronary and structural heart disease. Despite the misconception that coronary artery disease is a 'man's disease', contemporary data...
DEMENTIA is a term used to describe different types of brain degeneration. The most common type of dementia is Alzheimer ’s Disease, although vascular dementia and dementia with lewy bodies are also types. Symptoms of dementia include leaving items in the wrong place and memory loss. New research has provided hope for diagnosing dementia early, by finding that people with more yellow spots in their eye are more like ly to have the condition.
CONCLUSION: Therapist-assisted vision therapy increased peripheral visual awareness. Furthermore patients felt safer in the traffic and in outdoor activities. Reading speed significantly increased, and the ability to keep a moving object in focus improved. PMID: 29792389 [PubMed - as supplied by publisher]
In conclusion, documentation is important, a critical part of advocacy and the development process at the larger scale. It isn't just words, but rather a vital structural flow of information from one part of the larger community to another, necessary to sustain progress in any complex field. We would all do well to remember this - and to see that building this documentation is an activity in which we can all pitch in to help. Evidence Suggests that, at Least in Earlier Stages, Alzheimer's Disease Blocks Rather than Destroys Memories https://www.fightaging.org/archives/2017/07/evidence-suggests-that-at-least-in-ea...